Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SLC4A8 contributors: mct - updated : 08-04-2014
HGNC name solute carrier family 4, sodium bicarbonate cotransporter, member 8
HGNC id 11034
Location 12q13.13      Physical location : 51.818.593 - 51.902.980
Synonym name
  • sodium/bicarbonate cotransporter 3
  • solute carrier family 4 member 8
  • Na+-driven Cl-HCO3 exchanger
  • electroneutral sodium bicarbonate exchanger 1
  • sodium-driven chloride/bicarbonate exchanger
  • Synonym symbol(s) NBC3, NDCBE1, KIAA0739, DKFZp761B2318, NBC, FLJ46462, NDCBE
    DNA
    TYPE functioning gene
    STRUCTURE 124.45 kb     25 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    motif Viral sequence   long terminal repeat
    text structure specific HERV-K LTR within intron 5
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 4010 - 1044 - 2008 1857771
    25 - 11794 - 1093 - 2008 1857771
    25 - 11740 - 1040 - 2008 1857771
    15 - 2278 - 638 - 2008 1857771
    15 - 2332 - 691 - 2008 1857771
    - - 3131 - 747 - 2008 1857771
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart     Homo sapiens
    Nervousbrain     Homo sapiens
     brainforebraincerebral cortex   Mus musculus
     brain     Rattus norvegicusAdult
     brainforebraincerebral cortex   Mus musculus
     brainhindbraincerebellum   Mus musculus
     brainlimbic systemhippocampus   Mus musculus
    Reproductivemale systemtestis    Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    Muscularstriatumskeletal   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervouspyramidal cell Mus musculus
    Visualcone photoreceptor
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C terminal PDZ-interacting motifs
  • HOMOLOGY
    interspecies homolog to murine Ncbe
    intraspecies homolog to SLC4A5
    Homologene
    FAMILY
  • anion exchanger (TC 2.A.31) family
  • SLC4 family of bicarbonate transporters
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • is in most glutamatergic axon terminals, and is also present in the terminals of parvalbumin-positive GABAergic cells
  • basic FUNCTION
  • playing an essential role in maintaining sensory cells integrity in both visual and auditory systems
  • having inorganic anion exchanger activity
  • is in a position to contribute substantially to pH(i) regulation in multiple CNS neurons
  • potential role in mediating substantial Na+ reabsorption in the cortical collecting duct (CCD)
  • modulates potentially glutamate release in a pH-dependent manner
  • modulate excitatory neurotransmission in hippocampus
  • can regulate glutamatergic transmission throughout the brain, and is a possible regulator of GABAergic neurotransmission
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CA2 interacts at high affinity with the C-terminal (Ct) domains of SLC4A8, but can bind to GST-SLC4-Ct fusion proteins only when the CA2 is immobilized and the fusion protein is soluble, and not vice versa
  • cell & other
    REGULATION
    Other its activity is inhibited by PRKACA and depends on the integrity of the actin cytoskeleton within a multiprotein complex at the plasma membrane
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS