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FLASH GENE
Symbol SLC4A7 contributors: mct - updated : 20-08-2015
HGNC name solute carrier family 4, sodium bicarbonate cotransporter, member 7
HGNC id 11033
Location 3p24.1      Physical location : 27.414.214 - 27.498.245
Synonym name
  • sodium bicarbonate cotransporter 2
  • sodium bicarbonate cotransporter 3
  • bicarbonate transporter
  • solute carrier family 4, sodium bicarbonate cotransporter, member 6
  • Synonym symbol(s) NBC3, NBC2, SBC2, SLC4A6, BT, DKFZp686H168, NBC2B, NBCN1
    DNA
    TYPE functioning gene
    STRUCTURE 111.07 kb     25 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    FLJ25157 3p24.2 hypothetical protein FLJ25157 UBE2E1 3p24.1 ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast) KBRAS1 3p24.1 I-kappa-B-interacting Ras-like protein 1 RPL15 3p12-p11.2 ribosomal protein L15 NR1D2 3p24.3-p24.2 nuclear receptor subfamily 1, group D, member 2 LOC391520 3 similar to nucleolar phosphoprotein B23.2 - rat THRB 3p24 thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian) LOC285324 3p24.1 similar to Retinoic acid receptor beta (RAR-beta) (RAR-epsilon) (HBV-activated protein) LOC391521 3 similar to Cofilin, non-muscle isoform LOC51036 3p24 retinoic acid receptor-beta associated open reading frame RARB 3p24.3 retinoic acid receptor, beta TOP2B 3p24 topoisomerase (DNA) II beta 180kDa LOC391522 3 similar to Cysteine-rich protein 1 (Cysteine-rich intestinal protein) (CRIP) NGLY1 3p24.1 N-glycanase 1 LOC246135 3p24.1 TBP-associated factor 9-like pseudogene FLJ12409 3p24.1 hypothetical protein FLJ12409 FLJ20604 3p24.1 hypothetical protein FLJ20604 LOC285326 3p24.1 hypothetical protein LOC285326 LOC391523 3 similar to Ribulose-phosphate 3-epimerase (Ribulose-5-phosphate-3-epimerase) (HUSSY-17) VENTX2P4 3p24.1 VENT-like homeobox 2 pseudogene 4 LRP15 3p24 hypothetical protein LRP15 FLJ32685 3p24.1 hypothetical protein FLJ32685 SLC4A7 3p22 solute carrier family 4, sodium bicarbonate cotransporter, member 7 LOC285321 3p23 similar to tropomyosin 4 EOMES 3p21.3-p21.2 eomesodermin homolog (Xenopus laevis) MGC61571 3p23 hypothetical protein MGC61571 AZ2 3p23 5-azacytidine induced gene 2 LOC152098 3p23 hypothetical protein LOC152098 FLJ33651 3p23 hypothetical protein FLJ33651 LOC131572 3p23 similar to MEST LOC389100 3 LOC389100 RBMS3 3p24.3-p23 RNA binding motif, single stranded interacting protein TGFBR2 3p22 transforming growth factor, beta receptor II (70/80kDa) LOC339896 3p23-p22.3 hypothetical protein LOC339896 LOC339897 3p22.3 similar to calponin 2; Calonin 2 LOC391524 3 similar to Thyroid hormone receptor-associated protein complex 150 kDa component (Trap150)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    25 - 7767 135.9 1214 - 2007 19638364
    25 - 7741 - 1131 - 2007 19638364
    24 - 7395 - 1090 - 2007 19638364
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon   Homo sapiens
     intestinelarge intestinerectum   Homo sapiens
     salivary glandparotid  highly Homo sapiens
    Hearing/Equilibriumearinnercochlea  
    Reproductivemale systemprostate  highly
    Visualeyeretina   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Hearing / Equilibriumstereocilia
    Visualcone photoreceptor
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • twelve membrane spanning domains protein with intracellular N and C termini
  • a PDZ-binding motif mediating interaction with the CFTR, SLC9A3R1 complex and probably with USH1C
  • HOMOLOGY
    interspecies homolog to rattus Slc4a7 (93.8pc)
    homolog to murine Slc4a7 (94.6pc)
    Homologene
    FAMILY
  • solute carrier family 4, chloride-bicarbonate
  • anion exchanger family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    text
  • USH2A, MASS1 and SLC4A7 are co-expressed with the USH1-protein harmonin in the synaptic terminals of both retinal photoreceptors and inner ear hair cells
  • localizes in mitochondria and suppresses the ischaemia-induced activation of the mitochondrial pathway of apoptosis in coronary endothelial cells
  • basic FUNCTION
  • may play a role in bicarbonate salvage in secretory epithelia
  • may also have an associated sodium channel activity
  • stable association of SLC4A7 at the membrane may facilitate constitutive uptake of HCO(3)(-) across the basolateral membrane (BLM)
  • in the kidney medullary thick ascending limb cell line is upregulated under acidic conditions and enhances ammonium transport
  • is electroneutral because it has an apparent stoichiometry of 1:1
  • plays an essential role in intracellular pH regulation and transepithelial HCO(3)(-) movement in the body
  • plays a critical role in pHi regulation in colonic epithelial cells
  • catalyzes the electroneutral movement of 1 Na(+):1 HCO3(-) into kidney cells
  • plays a role in transepithelial HCO3 (-) movement and intracellular pH maintenance in many tissues
  • plays a role in neutralizing intracellular acid loads at the basolateral membrane in cells of the medullary thick ascending limb (mTAL)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the postsynaptic density protein DLG4 in the brain, and DLG4 increases its channel-like activity while negligibly affecting Na/HCO(3) cotransport
  • physically and functionally associated with a variety of membrane and cytosolic proteins via the binding partners
  • binds to many PDZ proteins, which in turn may allow the transporter to associate with other physiologically important proteins
  • cell & other
    REGULATION
    Other regulated by CFTR (Park 2002)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility may be potential causative gene for breast cancer (Ahmed 2009)
    Variant & Polymorphism SNP allelic variants might alter disposition and/or excretion of drugs and neurotransmitters in brain and periphery in ways that could contribute to differential vulnerabilities to addictions (Ishiguro 2007)
    Candidate gene
  • for USH2B
  • for the contribution to vulnerability to addictions (Ishiguro 2007)
  • Marker
    Therapy target
    ANIMAL & CELL MODELS