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FLASH GENE
Symbol SLC4A5 contributors: mct/npt - updated : 31-03-2010
HGNC name solute carrier family 4, sodium bicarbonate cotransporter, member 5
HGNC id 18168
Location 2p13.1      Physical location : 74.443.369 - 74.570.534
Synonym name
  • sodium bicarbonate transporter 4
  • electrogenic sodium bicarbonate cotransporter 4
  • Synonym symbol(s) NBC4, MGC129662
    DNA
    TYPE functioning gene
    SPECIAL FEATURE
    text encoded by the same locus than DCTN1
    STRUCTURE 127.17 kb     26 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    alternative promoter
    MAPPING cloned Y linked N status provisional
    Physical map
    ACTG2 2p13.1 actin, gamma 2, smooth muscle, enteric DGUOK 2p24.3-p24.1 deoxyguanosine kinase LOC388961 2 LOC388961 MGC22014 2p13.1 hypothetical protein MGC22014 MGC10955 2p13.1 hypothetical protein MGC10955 LOC388962 2 similar to RIKEN cDNA 1810056O20 C2orf6 2p12 chromosome 2 open reading frame 6 MTHFD2 2p12 methylene tetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase SLC4A5 2p13 solute carrier family 4, sodium bicarbonate cotransporter, member 5 DCTN1 2p13 dynactin 1 (p150, glued homolog, Drosophila) LOC388963 2 similar to Retinol dehydrogenase 12 LOC257200 2p13.1 similar to high mobility group AT-hook 1 FLJ12953 2p13.1 hypothetical protein FLJ12953 similar to Mus musculus D3Mm3e RTKN 2p13 rhotekin HMGA1L4 2p13.1 high mobility group AT-hook 1-like 4 WBP1 2p12 WW domain binding protein 1 GCS1 2p13 WW domain binding protein 1 MRPL53 2p13.1 mitochondrial ribosomal protein L53 LOC151534 2p13.1 hypothetical protein BC009264 FLJ14397 2p13.1 hypothetical protein FLJ14397 FLJ12788 2p13.1 hypothetical protein FLJ12788 NSPC1 2p13.1 likely ortholog of mouse nervous system polycomb 1 TLX2 2p13.1-p12 T-cell leukemia, homeobox 2 DQX1 2p12 T-cell leukemia, homeobox 2 AUP1 2p13 ancient ubiquitous protein 1 PRSS25 2p13.3 protease, serine, 25 LOXL3 2p13.3 lysyl oxidase-like 3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    26 - 3449 12.3 1137 - Pushkin, Stutz (2009)
    variant a
    - splicing 3810 11.6 1074 liver,spleen,heart moderatly Pushkin (2000)
    frameshift and premature termination
    31 splicing 6364 12.1 1121 liver Sassani, Stutz (2009)
    variant c
    - splicing 3500 11.2 1040 liver Pushkin (2000)
    - - - - - in liver Xu (2003)
    sequence of this variant (called NBC4e) is shorter by 86 amino acids
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   moderately
    Cardiovascularheart   moderately
    Digestiveliver   moderately
    Reproductivemale systemtestis   
    Urinarykidneyrenal medulla  highly
     kidneytubuleHenles loopHL ascending limb 
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 12 putative transmembrane spanning domain
  • a unique glycine-rich region
  • only one stilbene binding motif
  • HOMOLOGY
    intraspecies homolog to NBC1
    Homologene
    FAMILY
  • xanthine/uracil permease family
  • anion exchanger (TC 2.A.31) family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • mediates cellular HCO(3)(-) uptake in the thick ascending limb of the loop of Henle (Xu 2003)
  • may plays a role in mediating Na(+)-HCO(3)(-) cotransport in hepatocytes and intrahepatic cholangiocytes (Abdulaze 2004)
  • protein that transports sodium and bicarbonate across the cell membrane and regulates cellular pH (Hunt 2006)
  • involvement of SLC4A5 with blood pressure control (Hunt 2006)
  • involvement of SLC4A5 with blood pressure control
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS