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FLASH GENE
Symbol SLC47A2 contributors: mct/npt/pgu - updated : 07-10-2015
HGNC name solute carrier family 47, member 2
HGNC id 26439
Location 17p11.2      Physical location : 19.581.628 - 19.620.043
Synonym name
  • H+/organic cation antiporter
  • multidrug and toxin extrusion 2
  • kidney-specific H(+)/organic cation antiporter
  • Synonym symbol(s) FLJ31196, MATE2, MATE2-B, MATE2-K, MATE2K
    DNA
    TYPE functioning gene
    STRUCTURE 38.42 kb     17 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 splicing 2247 - 566 - 2011 21419862
  • has an exon deleted
  • both MATE2 and MATE2K equally operate in the human kidneys to extrude organic cations into the urine
  • 17 - 2355 - 602 - 2011 21419862
  • MATE2
  • both MATE2 and MATE2K equally operate in the human kidneys to extrude organic cations into the urine
  • EXPRESSION
    Rna function mRNA expressed in the kidneys
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Urinarykidneytubuleconvoluted tubuleproximal tubule  Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialabsorptive excretoryrenal tubular epithelium   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Urinaryepithelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • multidrug and toxic compound extrusion (MATE) proteins family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • localized in intracellular vesicular structures
  • basic FUNCTION
  • play important roles in the renal tubular secretion of cationic drugs
  • able to transport tetraethylammonium (TEA) utilizing an oppositely directed H+ gradient as a driving force
  • play crucial roles in the renal handling of cationic drugs, such as cimetidine, metformin and oxaliplatin
  • function together as a detoxication system, by mediating the tubular secretion of intracellular ionic compounds across the brush-border membranes of the kidney
  • kidney-specific H+/organic cation antiporter that is responsible for the tubular secretion of cationic drugs across the brush border membranes
  • responsible for the final step in the excretion of metabolic waste and xenobiotic organic cations in the kidney and liver through electroneutral exchange of H(+)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to drug-induced nephrotoxicity
    Variant & Polymorphism SNP significant decrease in transport activity, and especially G211V were completely abolished by the impairment of cell surface expression leading to drug-induced nephrotoxicity
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS