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FLASH GENE

Symbol

SLC45A1

contributors: mct - updated : 07-06-2017

HGNC name	solute carrier family 45, member 1
HGNC id	17939

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	SLC45A1D SLC45A1deficiency
Location	1p36.23      Physical location : 8.384.389 - 8.404.226
Synonym name	deleted in neuroblastoma 5
	proton-associated sugar transporter A
Synonym symbol(s)	DNB5, PAST-A, KIAA0458, FLJ26758

DNA

TYPE	functioning gene
STRUCTURE	26.08 kb     8 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

Map	pter - DNB6 - DNB3 - RERE - DNB2 - SLC45A1 - cen
Authors	Amler (00)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001080397 8 - 2527 NP_001073866 - 782 - 2000 10729226

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Nervous brain forebrain cerebral cortex   predominantly Homo sapiens Adult   brain       highly Homo sapiens Fetal   brain hindbrain cerebellum   highly Homo sapiens Adult Urinary kidney

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	kidney, brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

glycoside-pentoside-hexuronide (GPH) cation symporter transporter family

CATEGORY

tumor suppressor , transport

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	sugar transporter activity
	proton-associated glucose transporter
	neuronal glucose transporter, that represent the second cerebral glucose transporter, along with SLC02A1, to be involved in neurodevelopmental disability
	is likely a H+ and glucose symporter
	might likely play a role in the regulation of respiration, possibly by controlling energy production in ventral medullary surface (VMS) of the medullary oblongata neurons

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

SLC45A1D

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     in neuroblastoma

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS