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FLASH GENE
Symbol SLC43A1 contributors: - updated : 24-02-2006
HGNC name solute carrier family 43, member 1
HGNC id 9225
Location 11p11.2-p11.1      Physical location : 57.252.007 - 57.283.159
Synonym name
  • L-type amino acid transporter 3
  • prostate cancer overexpressed gene 1
  • large neutral amino acids transporter small subunit 3
    • Synonym symbol(s) LAT3, PB39, POV1, R00504
    DNA
    TYPE functioning gene
    STRUCTURE 31.00 kb     16 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     liver    
    Lymphoid/Immunelymph node    
    Reproductivemale systemprostate   
    Visualeye    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text tissues, eye, liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminus contains charged amino acids and a helical loop pattern suggestive of an SRP leader sequence for a secreted protein
  • a putative secretory signal peptide
  • a leucine zipper motif
  • eight transmembrane domains
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Slc43a1
    Homologene
    FAMILY organic solute transporters family
    CATEGORY protooncogene , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • transporting neutral amino acids such as l-leucine, l-isoleucine, l-valine, transport Na+-independent
  • playing a role in the development of prostate cancer
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS