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FLASH GENE
Symbol SLC41A1 contributors: mct - updated : 22-01-2013
HGNC name solute carrier family 41, member 1
HGNC id 19429
Location 1q32.1      Physical location : 205.758.220 - 205.782.161
Synonym symbol(s) MgtE
DNA
TYPE functioning gene
STRUCTURE 23.94 kb     11 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
MDM4 1q32 Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse) GAC1 NFASC 1q32.1 Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse) CNTN2 1q32.1 contactin 2 (axonal) LOC388730 1 similar to RIKEN cDNA 4930429O20 RBBP5 1q32 retinoblastoma binding protein 5 KIAA0472 HUCEP11 1q32.1 retinoblastoma binding protein 5 SNARK 1q32 Homo sapiens likely ortholog of rat SNF1/AMP-activated protein kinase (SNARK), mRNA. FLJ10748 1q32.1 hypothetical protein FLJ10748 LOC93273 1q32.1 hypothetical protein LOC93273 PCTK3 1q31-q32 PCTAIRE protein kinase 3 DKFZp761N1114 1q32.1 hypothetical protein DKFZp761N1114 ELK4 1q32 ELK4, ETS-domain protein (SRF accessory protein 1) Prostein 1q32.1 prostein protein NUCKS 1q31.1 prostein protein RAB7L1 1q32 RAB7, member RAS oncogene family-like 1 SLC41A1 1q32.1 solute carrier family 41, member 1 LOC388731 1 hypothetical gene supported by AK097788 FLJ32569 1q32.1 hypothetical protein FLJ32569 SLC26A9 1q31-q32 solute carrier family 26, member 9 LOC391156 1 LOC391156 FNBP2 1q31.3 formin binding protein 2 IKBKE 1q32.1 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon RASSF5 1q32.1 Ras association (RalGDS/AF-6) domain family 5 LGTN 1q31-q32 ligatin DYRK3 1q32 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 MAPKAPK2 1q32 mitogen-activated protein kinase-activated protein kinase 2 IL10 1q31.3-q32.1 interleukin 10 IL19 1q32.2 interleukin 19 IL20 1q32 interleukin 20
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 4869 - 513 - 2005 15713785
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrinethyroid   highly
Lymphoid/Immunelymph node   highly
Reproductivemale systemprostate   
Respiratorylung    
Visualeyeanterior segmentiris  
 eyeretina   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialabsorptive excretoryrenal tubular epithelium  
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ten putative transmembrane domains
  • two distinct domains highly homologous to the integral membrane part of the bacterial MgtE protein family
  • HOMOLOGY
    Homologene
    FAMILY MgtE family of Mg(2+) transporters
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may be having have cation transporter activity
  • regulated Mg2+ transporter that might be involved in magnesium homeostasis in epithelial cells
  • acting as a carrier mediating magnesium efflux
  • Mg2+ carrier playing a significant role in transmembrane Mg2+ transport and, by extrapolation, in cellular Mg2+ homeostasis
  • having a novel plasma membrane Mg(2+) transport function
  • encodes for the Na(+)/Mg(2+) exchanger, the predominant Mg(2+) efflux system
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • central component of vertebrate Mg(2+) transport systems, and its Mg(2+) transport function is regulated primarily through an endosomal recycling mechanism involving the SLC41A1 N-terminal cytoplasmic domain
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to Parkinson disease (PARK16)
  • Variant & Polymorphism other three variants increasing the risk of Parkinson disease
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS