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FLASH GENE
Symbol SLC41A1 contributors: mct - updated : 22-01-2013
HGNC name solute carrier family 41, member 1
HGNC id 19429
Location 1q32.1      Physical location : 205.758.220 - 205.782.161
Synonym symbol(s) MgtE
DNA
TYPE functioning gene
STRUCTURE 23.94 kb     11 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 4869 - 513 - 2005 15713785
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrinethyroid   highly
Lymphoid/Immunelymph node   highly
Reproductivemale systemprostate   
Respiratorylung    
Visualeyeanterior segmentiris  
 eyeretina   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialabsorptive excretoryrenal tubular epithelium  
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ten putative transmembrane domains
  • two distinct domains highly homologous to the integral membrane part of the bacterial MgtE protein family
  • HOMOLOGY
    Homologene
    FAMILY MgtE family of Mg(2+) transporters
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may be having have cation transporter activity
  • regulated Mg2+ transporter that might be involved in magnesium homeostasis in epithelial cells
  • acting as a carrier mediating magnesium efflux
  • Mg2+ carrier playing a significant role in transmembrane Mg2+ transport and, by extrapolation, in cellular Mg2+ homeostasis
  • having a novel plasma membrane Mg(2+) transport function
  • encodes for the Na(+)/Mg(2+) exchanger, the predominant Mg(2+) efflux system
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • central component of vertebrate Mg(2+) transport systems, and its Mg(2+) transport function is regulated primarily through an endosomal recycling mechanism involving the SLC41A1 N-terminal cytoplasmic domain
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to Parkinson disease (PARK16)
  • Variant & Polymorphism other three variants increasing the risk of Parkinson disease
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS