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FLASH GENE
Symbol SLC39A9 contributors: mct - updated : 08-09-2021
HGNC name solute carrier family 39 (zinc transporter), member 9
HGNC id 20182
Location 14q24.1      Physical location : 69.865.406 - 69.929.105
Synonym name
  • Zrt- and Irt-like protein 9
  • solute carrier family 39 member 9
  • Synonym symbol(s) FLJ11274, MGC74989, ZIP9
    DNA
    TYPE functioning gene
    STRUCTURE 64.02 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 5399 32.12 307 - 2018 30262433
    7 - 4845 - 189 - 2018 30262433
    8 - 4833 - 189 - 2018 30262433
    7 - 2065 - 232 - 2018 30262433
    6 - 4330 - 284 - 2018 30262433
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsensoryolfactory  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymhoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • SLC39A family of zinc transporters
  • KE4/catsup subfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • would be involved in heavy metal ion transport
  • ZIP9 functions likely to regulate zinc homeostasis in the secretory pathway without significantly altering cytosolic zinc homeostasis
  • regulates cytosolic zinc level, resulting in the enhancement of AKT1 and ERK phosphorylation
  • is a Zn2+ transporter, testosterone receptor, and mediator of signaling events through G-proteins
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • enhance AKT1 and ERK1 and ERK2 phosphorylation in immune cells by regulating intracellular zinc concentration
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional fusion      
    PLEKHD1-SLC39A9 in schizophrenia
    tumoral       gain of function
    in malignant breast and prostate tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    potential therapeutic target for treating breast and prostate cancers
    cancerreproductiveprostate
    potential therapeutic target for treating breast and prostate cancers
    ANIMAL & CELL MODELS