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FLASH GENE

Symbol

SLC39A7

contributors: SGE - updated : 13-01-2007

HGNC name	solute carrier family 39 (zinc transporter), member 7
HGNC id	4927

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6p21.3      Physical location : 4.400.825 - 33.172.213
Synonym name	HLA class II region expressed gene KE4
	Ke4 gene, mouse, human homolog of
Synonym symbol(s)	KE4, HKE4, RING5, H2-KE4, D6S115E, D6S2244E, RING5, ZIP7

DNA

TYPE	functioning gene
STRUCTURE	3.60 kb     8 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed V1 8 - 2172 49.9 469 - Kim V2 7 - 2475 49.9 469 - Kim

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen         Digestive esophagus       highly   stomach       highly Lymphoid/Immune lymph node         Nervous nerve spinal nerve sciatic   highly Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Nervous central       Nervous peripherous

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

histidine-rich charge clusters

HOMOLOGY

interspecies

homolog to murine Ke4

Homologene

FAMILY	ZIP transporter (tc 2.a.5) family
	KE4/catsup subfamily

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
text	on intracellular membranes, including the endoplasmic reticulum

basic FUNCTION	would be involved in heavy metal ion transport
	involved in the control of intracellular zinc homeostasis
	functional zinc transporter that acts by transporting zinc from the Golgi apparatus to the cytoplasm of the cell
	releases zinc from endoplasmic reticulum and might be required for tyrosine kinase activation (Hogstrand 2009)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	heavy metal ion transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene	might be a novel target for diseases such as cancer where prevention of tyrosine kinase activation would be therapeutically advantageous (Hogstrand 2009)
Marker
Therapy target

ANIMAL & CELL MODELS