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FLASH GENE
Symbol SLC39A7 contributors: mct - updated : 12-11-2021
HGNC name solute carrier family 39 (zinc transporter), member 7
HGNC id 4927
Corresponding disease
AGM9 agammaglobulinemia 9, autosomal recessive
Location 6p21.32      Physical location : 4.400.825 - 33.172.213
Synonym name
  • HLA class II region expressed gene KE4
  • Ke4 gene, mouse, human homolog of
  • histidine-rich membrane protein Ke4
  • really interesting new gene 5 protein
  • zrt-, Irt-like protein 7
  • Synonym symbol(s) KE4, HKE4, RING5, H2-KE4, D6S115E, D6S2244E, ZIP7, AGM9
    DNA
    TYPE functioning gene
    STRUCTURE 3.60 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1826 - 344 - Kim
    7 - 2413 49.9 469 - Kim
    8 - 2110 - 469 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Digestiveesophagus   highly
     stomach   highly
    Lymphoid/Immunelymph node    
    Nervousnervespinal nervesciatic highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Nervouscentral   
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    histidine-rich charge clusters
    HOMOLOGY
    interspecies homolog to murine Ke4
    Homologene
    FAMILY
  • ZIP transporter (tc 2.a.5) family
  • KE4/catsup subfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,nucleoplasm
    text
  • on intracellular membranes, including the endoplasmic reticulum
  • resident endoplasmic reticulum (ER) protein that is involved in controlling the release of zinc from this organelle into the cytosol
  • basic FUNCTION
  • would be involved in heavy metal ion transport
  • involved in the control of intracellular zinc homeostasis
  • functional zinc transporter that acts by transporting zinc from the Golgi apparatus to the cytoplasm of the cell
  • releases zinc from endoplasmic reticulum and might be required for tyrosine kinase activation (Hogstrand 2009)
  • importance of ZIP7 in maintenance of intestinal epithelial homeostasis through the regulation of ER function in proliferative progenitor cells and maintenance of intestinal stem cells
  • likely ER-localized SLC39A7 can potentially sequester zinc to these histidine-rich regions and therefore provides a mechanism that is protective of this cellular structure
  • SLC39A7 relieves zinc deficiency to suppress alternative macrophage activation and impairment of phagocytosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text heavy metal ion transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • activation of SLC39A7 by CNSK2A1, a kinase that is antiapoptotic and promotes cell division, suggesting that SLC39A7 may provide a target for anticancer drug development
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AGM9
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    resulted in augmented ER stress and impaired receptor trafficking, thereby globally affecting downstream signaling
    Susceptibility
    Variant & Polymorphism
    Candidate gene might be a novel target for diseases such as cancer where prevention of tyrosine kinase activation would be therapeutically advantageous (Hogstrand 2009)
    Marker
    Therapy target
    ANIMAL & CELL MODELS