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FLASH GENE
Symbol SLC39A7 contributors: SGE - updated : 13-01-2007
HGNC name solute carrier family 39 (zinc transporter), member 7
HGNC id 4927
Location 6p21.3      Physical location : 4.400.825 - 33.172.213
Synonym name
  • HLA class II region expressed gene KE4
  • Ke4 gene, mouse, human homolog of
  • Synonym symbol(s) KE4, HKE4, RING5, H2-KE4, D6S115E, D6S2244E, RING5, ZIP7
    DNA
    TYPE functioning gene
    STRUCTURE 3.60 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2172 49.9 469 - Kim
    7 - 2475 49.9 469 - Kim
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Digestiveesophagus   highly
     stomach   highly
    Lymphoid/Immunelymph node    
    Nervousnervespinal nervesciatic highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Nervouscentral   
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    histidine-rich charge clusters
    HOMOLOGY
    interspecies homolog to murine Ke4
    Homologene
    FAMILY
  • ZIP transporter (tc 2.a.5) family
  • KE4/catsup subfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text on intracellular membranes, including the endoplasmic reticulum
    basic FUNCTION
  • would be involved in heavy metal ion transport
  • involved in the control of intracellular zinc homeostasis
  • functional zinc transporter that acts by transporting zinc from the Golgi apparatus to the cytoplasm of the cell
  • releases zinc from endoplasmic reticulum and might be required for tyrosine kinase activation (Hogstrand 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text heavy metal ion transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene might be a novel target for diseases such as cancer where prevention of tyrosine kinase activation would be therapeutically advantageous (Hogstrand 2009)
    Marker
    Therapy target
    ANIMAL & CELL MODELS