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FLASH GENE
Symbol SLC39A3 contributors: mct/npt - updated : 24-03-2010
HGNC name solute carrier family 39 (zinc transporter), member 3
HGNC id 17128
Location 19p13.3      Physical location : 2.732.524 - 2.740.074
Synonym name
  • Zrt- and Irt-like protein 3
  • zinc transporter
  • Synonym symbol(s) ZIP3
    DNA
    TYPE functioning gene
    STRUCTURE 7.55 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    MGC39696 19p13.3 hypothetical protein MGC39696 CSNK1G2 19p13.3 casein kinase 1, gamma 2 BTBD2 19p13.3 BTB (POZ) domain containing 2 MKNK2 19p13.3 MAP kinase-interacting serine/threonine kinase 2 moblak IMAGE:4215339 19p13.3 hypothetical protein IMAGE:4215339 AP3D1 19p13.3 adaptor-related protein complex 3, delta 1 subunit DOT1L 19p13.3 adaptor-related protein complex 3, delta 1 subunit SF3A2 19p13.3 splicing factor 3a, subunit 2, 66kDa GNRPX 19p13.3 likely ortholog of mouse guanine nucleotide releasing protein x AMH 19p13.3 anti-Mullerian hormone FLJ32416 19p13.3 homolog of mouse skeletal muscle sarcoplasmic reticulum protein JP-45 OAZ1 19p13.3 ornithine decarboxylase antizyme 1 FLJ45778 19p13.3 FLJ45778 protein LOC388489 19 hypothetical gene supported by AK091795 LSM7 19p13.3 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) SPPL2B 19p13.3 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) LOC360200  polyserase 1 TIMM13 19p13.3 translocase of inner mitochondrial membrane 13 homolog (yeast) LMNB2 19p13.3 lamin B2 GADD45B 19p13.3 growth arrest and DNA-damage-inducible, beta FLJ00058 19p13.3 hypothetical protein FLJ00058 GNG7 19p13.3 guanine nucleotide binding protein (G protein), gamma 7 LOC390875 19 similar to fos39347_1 DIRAS1 19p13.3 DIRAS family, GTP-binding RAS-like 1 LOC388490 19 LOC388490 SLC39A3 19p13.3 solute carrier family 39 (zinc transporter), member 3 SGTA 19p13 small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha THOP1 19p13.3 thimet oligopeptidase 1 FLJ34817 19p13.3 hypothetical protein FLJ34817 MGC26707 19p13.3 hypothetical protein MGC26707 FLJ11637 19p13.3 hypothetical protein FLJ11637 LOC126295 19p13.3 hypothetical protein LOC126295 ZNF77 19p zinc finger protein 77 (pT1) FLJ14009 19p13.3 transducin-like enhancer protein 6 TLE2 19p13.3 transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila) AES 19p13.3 amino-terminal enhancer of split GNA11 19p13.3 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) LOC390876 19 similar to ribosomal protein L35 GNA15 19p13.3 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) LOC388491 19 similar to KIAA1683 protein EDG6 19p13.3 endothelial differentiation, G-protein-coupled receptor 6 LOC56926 19p13.3 hypothetical protein from EUROIMAGE 2021883 BRUNOL5 19p13 bruno-like 5, RNA binding protein (Drosophila)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1441 - 314 - Dufner-Beattie (2003)
    2 - 3005 - 105 - Dufner-Beattie (2003)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • eight-transmembrane domain proteins with a conserved 12-AAs signature sequence within the fourth transmembrane domain (Dufner-Beattie 2003)
  • HOMOLOGY
    Homologene
    FAMILY
  • ZIP transporter family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • localized predominantly at the apical cell membrane (Desouki 2007)
  • basic FUNCTION
  • di,tri-valent inorganic cation transporter
  • maybe play cell-specific roles in zinc homeostasis rather than primary roles in the acquisition of dietary zinc (Dufner-Beattie 2003)
  • appear to be important for retention of the zinc in the cellular compartment (Desouki 2007)
  • seemingly associated with the re-uptake of zinc from prostatic fluid (Desouki 2007)
  • important zinc uptake transporter involved in the unique ability of prostate cells to accumulate high cellular zinc levels (Desouki 2007)
  • primarily plays a role in the reuptake and cellular retention of Zn in the mammary gland from the previously secreted milk pool, thus regulating cellular function (Kelleher 2009)
  • have unique cell-specific functions during adaptation to zinc deficiency (Kambe 2009)
  • is the important transporter required for the accumulation of zinc and its inhibition of proliferation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in prostate adenocarcinoma (Desouki 2007)
    tumoral     --low  
    the pathway of RREB1/SLC39A3/Zinc and its downregulation during oncogenesis exist to prevent the accumulation of cytotoxic levels of zinc during the development and progression of the malignant cells in pancreatic adenocarcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS