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FLASH GENE
Symbol SLC39A14 contributors: mct - updated : 30-03-2015
HGNC name solute carrier family 39 (zinc transporter), member 14
HGNC id 20858
Corresponding disease
HMNDYT2 hypermanganesemia with dystonia 2
Location 8p21.2      Physical location : 22.224.761 - 22.291.638
Synonym name
  • Zrt-, Irt-like protein 14
  • Synonym symbol(s) KIAA0062, LZT-Hs4, ZIP14, cig19, NET34, ZRT/IRT-like 14
    DNA
    TYPE functioning gene
    STRUCTURE 66.88 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    Physical map
    GFRA2 8p22-p21 GDNF family receptor alpha 2 DOK2 8p21.2 docking protein 2, 56kDa XPO7 8p21 exportin 7 NPM2 8p21.3 nucleophosmin/nucleoplasmin, 2 FGF17 8p21 fibroblast growth factor 17 EPB49 8p21.1 erythrocyte membrane protein band 4.9 (dematin) RAI16 8p21.2 retinoic acid induced 16 FLJ22494 8p21.3 hypothetical protein FLJ22494 HR 8p22-p21 hairless homolog (mouse) FLJ22246 8p21.3 hypothetical protein FLJ22246 LGI3 8p21.2 leucine-rich repeat LGI family, member 3 SFTPC 8p21.2 surfactant, pulmonary-associated protein C BMP1 8p21.2 bone morphogenetic protein 1 PHYHIP 8p21.2 phytanoyl-CoA hydroxylase interacting protein POLR3D 8q21 polymerase (RNA) III (DNA directed) polypeptide D, 44kDa PIWIL2 8p21.2 piwi-like 2 (Drosophila) SLC39A14 8p21.2 solute carrier family 39 (zinc transporter), member 14 PPP3CC 8p21.2 protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (calcineurin A gamma) LOC389639 8 LOC389639 SCAM-1 8p21.2 vinexin beta (SH3-containing adaptor molecule-1) PDLIM2 8p21.2 PDZ and LIM domain 2 (mystique) DBC-1 8p22 p30 DBC protein BIN3 8p21.2 bridging integrator 3 FLJ14107 8p21.2 hypothetical protein FLJ14107 EGR3 8p23-p21 early growth response 3 MGC22776 8p21.2 hypothetical protein MGC22776 RHOBTB2 8p21.2 Rho-related BTB domain containing 2 TNFRSF10B 8p21 tumor necrosis factor receptor superfamily, member 10b LOC389640 8 LOC389640 TNFRSF10C 8p21 tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain TNFRSF10D 8p21 tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain TNFRSF10A 8p21 tumor necrosis factor receptor superfamily, member 10a LOC389641 8 hypothetical gene supported by AK124295 MGC29816 8p21.2 hypothetical protein MGC29816 LOC203069 8p21.2 hypothetical protein LOC203069 LOXL2 8p21.3-p21.2 lysyl oxidase-like 2
    RNA
    TRANSCRIPTS type messenger
    text contains two mutually exclusive exons 4A and 4B and the exon 4A/4B ratio was significantly altered in adenomas and cancers (PMID: 20938052)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1793 - 481 - 2005 15642354
    9 - 4699 - 492 - 2005 15642354
    9 - 4699 - 492 - 2005 15642354
    9 - 4740 - 492 - 2005 15642354
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly Homo sapiens
    Digestiveintestine   highly Mus musculus
     liver   predominantly Rattus norvegicus
    Endocrinepancreas   highly Homo sapiens
    Reproductivemale systemtestis   
    Respiratoryrespiratory tracttrachea  highly
    Urinarykidney    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestivehepatocyte Homo sapiens
    Endocrineislet cell (alpha,beta...) Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a unique and highly conserved metalloprotease motif (HEXPHEXGD) in transmembrane domain V with both histidine residues essential for zinc transport by ZIP (Zrt-, Irt-like Proteins) transporters
  • HOMOLOGY
    Homologene
    FAMILY
  • LZT (LIV-1 subfamily of ZIP zinc Transporters) subfamily of zinc influx transporters
  • SLC39A zinc transporter family
  • ZIP family of metal-ion transporters
  • CATEGORY transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    text
  • is expressed in early endosomes, where it promotes the assimilation of iron from transferrin
  • basic FUNCTION
  • would be involved in heavy metal ion transport
  • involved in the control of intracellular zinc homoeostasis
  • glycosylated protein functioning as a zinc influx transporter in a temperature-dependant manner
  • plays a role as a zinc transporter during the early stages of adipogenesis
  • can mediate the uptake of zinc and non-transferrin-bound iron into cells and it may play a role in zinc and iron metabolism in hepatocytes, where this transporter is abundantly expressed
  • like SLC39A8, SLC39A14 proteins are glycosylated
  • can mediate the transport of iron at pH 6.5, the pH at which iron dissociates from transferrin within the endosome
  • endosomal form potentially participates in the cellular assimilation of iron from transferrin, thus identifying a potentially new role in iron metabolism
  • potentially playing a role in placental iron transfer
  • can participates in the assimilation of iron from transferrin in addition to playing a role in non-transferrin-bound iron uptake
  • controls G-Protein coupled receptor-mediated signaling required for systemic growth
  • can transport iron, zinc, manganese, and cadmium
  • plays more of a role than SLC11A2 in iron overload
  • may not only function during iron overload to take up non-transferrin-bound iron (NTBI), but also under normal or iron-deficient conditions when cells take up iron via endocytosis of transferrin
  • SLC30A10 and SLC39A14 are manganese efflux and influx transporters, respectively
  • transport activities of both SLC39A14 and SLC30A10 are required for hepatic manganese excretion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HMNDYT2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in embryonic carcinoma cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS