SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,organelle,endosome
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| text
| is expressed in early endosomes, where it promotes the assimilation of iron from transferrin  |
| basic FUNCTION
| would be involved in heavy metal ion transport |
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involved in the control of intracellular zinc homoeostasis |
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glycosylated protein functioning as a zinc influx transporter in a temperature-dependant manner |
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plays a role as a zinc transporter during the early stages of adipogenesis |
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can mediate the uptake of zinc and non-transferrin-bound iron into cells and it may play a role in zinc and iron metabolism in hepatocytes, where this transporter is abundantly expressed |
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like SLC39A8, SLC39A14 proteins are glycosylated |
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can mediate the transport of iron at pH 6.5, the pH at which iron dissociates from transferrin within the endosome |
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endosomal form potentially participates in the cellular assimilation of iron from transferrin, thus identifying a potentially new role in iron metabolism |
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potentially playing a role in placental iron transfer |
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can participates in the assimilation of iron from transferrin in addition to playing a role in non-transferrin-bound iron uptake |
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controls G-Protein coupled receptor-mediated signaling required for systemic growth |
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can transport iron, zinc, manganese, and cadmium |
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plays more of a role than SLC11A2 in iron overload |
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may not only function during iron overload to take up non-transferrin-bound iron (NTBI), but also under normal or iron-deficient conditions when cells take up iron via endocytosis of transferrin |
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SLC30A10 and SLC39A14 are manganese efflux and influx transporters, respectively |
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transport activities of both SLC39A14 and SLC30A10 are required for hepatic manganese excretion |
