basic FUNCTION
| acting as a putative sodium-dependent amino acid/proton antiporter |
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likely a role at the core of the amino acid-sensing mechanism |
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lysosomal membrane-resident protein competent in amino acid transport |
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is a physical and functional component of the amino acid sensing machinery that controls the activation of MTOR |
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SLC38A9 functions upstream of the Rag GTPases and is an excellent candidate for being an arginine sensor for the MTOR pathway |
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central role for SLC38A9 in amino acid homeostasis |
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SLC38A9 is necessary for leucine generated via lysosomal proteolysis to exit lysosomes and activate MTOR |
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is responsible for coupling amino acid transport across the lysosomal membrane according to the substrate availability to MTOR signal transduction |
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SLC38A9 is competent for glutamine efflux, while that of arginine is negligible |