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FLASH GENE
Symbol SLC38A9 contributors: mct - updated : 30-03-2022
HGNC name solute carrier family 38, member 9
HGNC id 26907
Location 5q11.2      Physical location : 54.921.675 - 55.008.163
Synonym name
  • up-regulated in lung cancer 11
  • putative sodium-coupled neutral amino acid transporter 9
  • Synonym symbol(s) FLJ90709, FLJ46104, MGC120544, URLC11
    DNA
    TYPE functioning gene
    STRUCTURE 86.50 kb     16 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 2522 63.7 561 - 2020 32868926
    15 - 2410 - 437 - 2020 32868926
    15 - 2348 - 496 - 2020 32868926
    17 - 2656 - 561 - 2020 32868926
    18 - 2809 - 561 - 2020 32868926
    18 - 2812 - 561 - 2020 32868926
    14 - 2689 - 498 - 2020 32868926
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   moderately
     parathyroid   predominantly
    Reproductivemale systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to rattus Slc38a9 (91.4 pc)
    homolog to murine Slc38a9 (91.6 pc)
    Homologene
    FAMILY
  • amino acid/polyamine transporter 2 family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    text multi-pass membrane protein
    basic FUNCTION
  • acting as a putative sodium-dependent amino acid/proton antiporter
  • likely a role at the core of the amino acid-sensing mechanism
  • lysosomal membrane-resident protein competent in amino acid transport
  • is a physical and functional component of the amino acid sensing machinery that controls the activation of MTOR
  • SLC38A9 functions upstream of the Rag GTPases and is an excellent candidate for being an arginine sensor for the MTOR pathway
  • central role for SLC38A9 in amino acid homeostasis
  • SLC38A9 is necessary for leucine generated via lysosomal proteolysis to exit lysosomes and activate MTOR
  • is responsible for coupling amino acid transport across the lysosomal membrane according to the substrate availability to MTOR signal transduction
  • SLC38A9 is competent for glutamine efflux, while that of arginine is negligible
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text
  • sodium-dependent amino acid/proton antiporter
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Na+
  • protein
  • lysosomal transmembrane protein, SLC38A9, is required for MTOR activation by cholesterol through conserved cholesterol-responsive motifs
  • NPC1 protein, which regulates cholesterol export from the lysosome, binds to SLC38A9 and inhibits MTOR signaling through its sterol transport function
  • TM4SF5 bound active MTOR upon arginine sufficiency and constitutively bound amino acid transporter SLC38A9
  • the amino acid-mediated activation of MTOR is regulated by the N-terminal domain of SLC38A9
  • SLC38A9 interacted with SLC36A1 and they enhanced each other's expression levels and locations on the lysosomal surface
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS