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FLASH GENE
Symbol SLC38A8 contributors: mct - updated : 15-01-2014
HGNC name solute carrier family 38, member 8
HGNC id 32434
Corresponding disease
FHONDA Foveal Hypoplasia and Optic-Nerve-Decussation Defects and Anterior segment dysgenesis
Location 16q23.3      Physical location : 84.043.388 - 84.075.762
DNA
TYPE functioning gene
STRUCTURE 32.37 kb     10 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 1308 46.6 435 - 2013 24290379
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus   lowly Homo sapiens
Nervousbrain   predominantly Homo sapiensAdult
 brain   predominantly Homo sapiensFetal
 spinal cord   predominantly Homo sapiensAdult
 spinal cord   predominantly Homo sapiensFetal
Reproductivemale systemtestis  lowly Homo sapiens
Urinarykidney   lowly Homo sapiens
Visualeyeretinafovea   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Visualcone photoreceptor Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to rattus Slc38a8 (82.1 pc)
homolog to murine Slc38a8 (82.6 pc)
Homologene
FAMILY
  • SLC38 sodium-coupled neutral amino acid transporter (SNAT) family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text multi-pass membrane protein
    basic FUNCTION
  • acting as a putative sodium-dependent amino acid/proton antiporter
  • orphan member of the SLC38 sodium-coupled neutral amino acid transporter (SNAT) family of proteins, which are widely expressed and predominantly have glutamine as their preferred substrate
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text sodium-dependent amino acid/proton antiporter
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Na+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) FHONDA
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS