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FLASH GENE
Symbol SLC38A7 contributors: mct - updated : 13-02-2012
HGNC name solute carrier family 38, member 7
HGNC id 25582
Location 16q21      Physical location : 58.700.297 - 58.718.674
Synonym name amino acid transporter
Synonym symbol(s) FLJ10815, FLJ12724, SNAT7
DNA
TYPE functioning gene
STRUCTURE 18.38 kb     12 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 2773 49.8 462 - 2008 18418736
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   highly
Digestivemouth   highly
Endocrineadrenal gland   highly
Nervousbrain   highly Homo sapiens
 spinal cord   moderately Homo sapiens
Reproductivefemale systemovary  moderately
 male systemtestis  highly
Urinarykidney   moderately
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to rattus Slc38a7 (94.4 pc)
homolog to murine Slc38a7 (95 pc)
Homologene
FAMILY
  • amino acid/polyamine transporter 2 family
  • SLC38 family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text
  • multi-pass membrane protein
  • cellular localization of the SLC38A7 protein, with high expression in the soma and axon )
  • basic FUNCTION
  • acting as a putative sodium-dependent amino acid/proton antiporter
  • unique in being the first system N transporter expressed in GABAergic and also other neurons
  • could have an important function for the reuptake and recycling of glutamate
  • may play a role in sustaining the glutamate neurotransmitter pool in the brain through the glutamine-glutamate cycle
  • has a role in pathways involved in both excitatory and inhibitory neurotransmission
  • having a function as a sodium-coupled amino acid transport in glutamatergic and GABAergic neurons in the brain
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text sodium-dependent amino acid/proton antiporter
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, other,
  • Na+
  • l-glutamine is the preferred substrate but also transports other amino acids with polar side chains, as well as l-histidine and l-alanine
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS