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FLASH GENE
Symbol SLC38A2 contributors: mct - updated : 31-05-2017
HGNC name solute carrier family 38, member 2
HGNC id 13448
Location 12q13.11      Physical location : 46.751.971 - 46.766.645
Synonym name
  • amino acid transporter 2
  • sodium-coupled neutral amino acid transporter 2
  • system A amino acid transporter 2
  • neutral amino acid transport system A
  • protein 40-9-1
  • Synonym symbol(s) ATA2, SAT2, PRO1068, KIAA1382, SNAT2
    DNA
    TYPE functioning gene
    STRUCTURE 14.58 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   enhancer
    text structure amino acid responsive SNAT2 genomic element that mediates the regulation has been localized to the first intron
  • ATF4 binds an amino acids response element within the promoter and mediates induction of SNAT2 in peripheral cell lines (Grewal 2009)
  • MAPPING cloned Y linked N status provisional
    Physical map
    NELL2 12q13.1-q13.12 NEL-like 2 (chicken) FKSG42 12q12 FKSG42 LOC51054 12q putative glycolipid transfer protein DKFZp313M0720 12q12-q13.11 hypothetical protein DKFZp313M0720 DKFZp686G052 SFRS2IP 12q12-q14.3 splicing factor, arginine/serine-rich 2, interacting protein SLC38A1 12p11.21 solute carrier family 38, member 1 SLC38A2 12q solute carrier family 38, member 2 LOC387853 12 hypothetical gene supported by BC014370 SLC38A4 12q12-q13 solute carrier family 38, member 4 LOC390310 12 similar to transient receptor protein 6 AMIGO2 12q13.11 amphoterin induced gene 2 MGC16044 12q13.11 hypothetical protein MGC16044 LOC387854 12 LOC387854 LOC387855 12 LOC387855 FLJ21908 12q13.11 hypothetical protein FLJ21908 P11 12q13.1 26 serine protease EPAC 12q13.1 Rap1 guanine-nucleotide-exchange factor directly activated by cAMP FLJ20489 12q13.11 hypothetical protein FLJ20489 HDAC7A 12q13.1 histone deacetylase 7A VDR 12q13.1 vitamin D (1,25- dihydroxyvitamin D3) receptor MGC5576 12q13.1 hypothetical protein MGC5576 COL2A1 12q13.1 collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital) LOC283389 12q13.12 hypothetical gene supported by BC029593 SENP1 12q12-q13 hypothetical gene supported by BC029593 PFKM 12q13.1 phosphofructokinase, muscle ASB8 12q13.12 ankyrin repeat and SOCS box-containing 8 LOC390311 12 similar to prohibitin LOC387856 12 similar to expressed sequence AI836003 LOC121275 12q13.12 similar to Olfactory receptor 10AD1 LOC341567 12q13.12 HANP1 FLJ31295 12q13.12 hypothetical protein FLJ31295 LOC390312 12 similar to olfactory receptor MOR160-1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 4961 55.8 506 - Sugawara (2000)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
     mouth   highly
    Nervousnerve   highly
    Reproductivefemale systemuteruscervix highly
    Respiratoryrespiratory tractlarynx  highly
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Muscularstriatumskeletal highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousastrocyte
    Nervousneuron
    cell lineage
    cell lines hepatoma cell line
    fluid/secretion
    at STAGE
    Text expressed in human placental trophoblast
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • putative transmembrane region
  • HOMOLOGY
    interspecies homolog to rattus Slc38a2 (88.3pc)
    homolog to murine Slc38a2 (89.3pc)
    Homologene
    FAMILY
  • amino acid/polyamine transporter 2 family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text constitutively low in neurons under physiological conditions but potently induced in response to depletion of neutral amino acids (Grewal 2009)
    basic FUNCTION
  • neutral amino acid uptake systeme A including alpha methylaminoisobutyric acid transport, Na(+) dependent, pH sensitive, in normal astrocytes
  • may function in the transport of amino acids at the blood- brain barrier and in the supply of maternal nutrients to the fetus through the placenta
  • with SLC38A1, are responsible for the increase in placental system A activity that occurs across gestation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associated with an anion conductance, which is activated by Na+ binding to the transporter and which is inhibited by the binding of the amino acid substrate (Zhang 2009)
  • KCTD7 regulates activity of the neuronal glutamine transporter SLC38A2
  • cell & other
    REGULATION
    induced by TGFB1 for stimulating vascular smooth muscle cell L-proline transport
    inhibited by N-methyl-D-glucamine and choline
    Other up-regulated upon hypertonic conditions and amino acid deprivation
    polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS