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FLASH GENE

Symbol

SLC38A2

contributors: mct - updated : 31-05-2017

HGNC name	solute carrier family 38, member 2
HGNC id	13448

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12q13.11      Physical location : 46.751.971 - 46.766.645
Synonym name	amino acid transporter 2
	sodium-coupled neutral amino acid transporter 2
	system A amino acid transporter 2
	neutral amino acid transport system A
	protein 40-9-1
Synonym symbol(s)	ATA2, SAT2, PRO1068, KIAA1382, SNAT2

DNA

TYPE	functioning gene
STRUCTURE	14.58 kb     16 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	Binding site   enhancer
text structure	amino acid responsive SNAT2 genomic element that mediates the regulation has been localized to the first intron
	ATF4 binds an amino acids response element within the promoter and mediates induction of SNAT2 in peripheral cell lines (Grewal 2009)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 16 - 4961 isoform 1 55.8 506 - Sugawara (2000)

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver           mouth       highly Nervous nerve       highly Reproductive female system uterus cervix   highly Respiratory respiratory tract larynx     highly Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     highly Muscular striatum skeletal   highly

cells

System Cell Pubmed Species Stage Rna symbol Nervous astrocyte Nervous neuron

cell lineage
cell lines	hepatoma cell line
fluid/secretion

at STAGE

Text	expressed in human placental trophoblast

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

putative transmembrane region

HOMOLOGY

interspecies	homolog to rattus Slc38a2 (88.3pc)
	homolog to murine Slc38a2 (89.3pc)

Homologene

FAMILY

amino acid/polyamine transporter 2 family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	plasma membrane
text	constitutively low in neurons under physiological conditions but potently induced in response to depletion of neutral amino acids (Grewal 2009)

basic FUNCTION	neutral amino acid uptake systeme A including alpha methylaminoisobutyric acid transport, Na(+) dependent, pH sensitive, in normal astrocytes
	may function in the transport of amino acids at the blood- brain barrier and in the supply of maternal nutrients to the fetus through the placenta
	with SLC38A1, are responsible for the increase in placental system A activity that occurs across gestation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	associated with an anion conductance, which is activated by Na+ binding to the transporter and which is inhibited by the binding of the amino acid substrate (Zhang 2009)
	KCTD7 regulates activity of the neuronal glutamine transporter SLC38A2

cell & other

REGULATION

induced by

TGFB1 for stimulating vascular smooth muscle cell L-proline transport

inhibited by

N-methyl-D-glucamine and choline

Other	up-regulated upon hypertonic conditions and amino acid deprivation
	polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS