Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SLC38A1 contributors: np/ - updated : 03-09-2007
HGNC name solute carrier family 38, member 1
HGNC id 13447
Location 12p13.11      Physical location : 46.576.842 - 46.663.208
Synonym name
  • amino acid transporter system A1, neutral, small short chain
  • weakly similar to transporter protein
  • N-system amino acid transporter
  • sodium-coupled neutral amino acid transporter 1
  • Synonym symbol(s) ATA1, SAT1, NAT2, EVI163, SNAT1
    DNA
    TYPE functioning gene
    STRUCTURE 86.37 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 8148 54 487 - 2004 15054072
    17 - 8487 54 487 - 2004 15054072
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrineneuroendocrinepituitary  highly
    Lymphoid/Immunelymph node   highly
    Reproductivefemale systemuteruscervix highly
     male systemprostate  highly
    Respiratorylung   moderately
    Urinarykidney   highly
    Visualeyeretina   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsensoryvisual  
    Muscularstriatumskeletal  
    Nervouscentral   
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    Nervousoptic nerve
    Visualganglion cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta, expressed in human placental trophoblast
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • eleven putative transmembrane spanning domains
  • HOMOLOGY
    interspecies homolog to murine Slc38a1
    Homologene
    FAMILY
  • amino acid/polyamine transporter 2 family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text extensively accumulated in the cytoplasm of pre-malignant liver and most hepatocellular carcinoma
    basic FUNCTION
  • important transporter of glutamine, an intermediate in the detoxification of ammonia and the production of urea
  • specific role in the uptake of glutamine involved in the generation of the neurotransmitter glutamate in retina
  • its activation confers growth and survival advantages in pre-malignant and malignant liver lesions
  • a key contributor to system A activity at term (System A-mediated amino acid transport across the placenta is important for the supply of neutral amino acids needed for fetal growth)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    repressed by taurine
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    activated in hepatocellular carcinoma tissues and also elevated in pre-malignant cirrhotic livers compared with normal livers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS