basic FUNCTION
| important transporter of glutamine, an intermediate in the detoxification of ammonia and the production of urea |
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specific role in the uptake of glutamine involved in the generation of the neurotransmitter glutamate in retina |
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its activation confers growth and survival advantages in pre-malignant and malignant liver lesions |
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a key contributor to system A activity at term (System A-mediated amino acid transport across the placenta is important for the supply of neutral amino acids needed for fetal growth) |
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N-glycosylated protein and N-glycosylation of SLC38A1 may play an important role in the transport of substrates across the cell membrane |
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SLC38A1 is an obesity-associated gene in brown adipose tissue (BAT) and a hypoxia-responsive gene in brown adipocytes |
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played an essential role in the development and progression of osteosarcoma |
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SLC38A1 is not merely a transporter accumulating glutamine for metabolic purposes, but a key component regulating several neuronal functions |
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promoted ischemic brain damage via MTOR-autophagy system |
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key role of SLC38A1 for newly formed GABA, in harmony with the existence of a glutamate/GABA-glutamine (GGG) cycle |