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FLASH GENE
Symbol SLC38A1 contributors: mct - updated : 16-03-2022
HGNC name solute carrier family 38, member 1
HGNC id 13447
Location 12q13.11      Physical location : 46.576.842 - 46.663.208
Synonym name
  • amino acid transporter system A1, neutral, small short chain
  • weakly similar to transporter protein
  • N-system amino acid transporter
  • sodium-coupled neutral amino acid transporter 1
  • Synonym symbol(s) ATA1, SAT1, NAT2, EVI163, SNAT1, GLNT
    DNA
    TYPE functioning gene
    STRUCTURE 86.01 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 7758 54 487 - 2004 15054072
    17 - 8487 54 487 - 2004 15054072
    16 - 7982 - 487 - 2004 15054072
    18 - 8220 - 487 - 2004 15054072
    17 - 7650 - 487 - 2004 15054072
    17 - 2885 - 503 - 2004 15054072
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  highly
    Hearing/Equilibriumearinnercochlea   Homo sapiens
    Lymphoid/Immunelymph node   highly
    Nervousbrain     Homo sapiens
    Reproductivefemale systemuteruscervix highly
     male systemprostate  highly
    Urinarykidney   highly
    Visualeyeretina   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsensoryvisual  
    Muscularstriatumskeletal  
    Nervouscentral   
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Hearing / Equilibriumhair cell receptor Homo sapiens
    Nervousneuron Homo sapiens
    Nervousoptic nerve
    Visualganglion cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta, expressed in human placental trophoblast
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • eleven putative transmembrane spanning domains
  • three de novo glycosylation sites
  • HOMOLOGY
    interspecies homolog to murine Slc38a1
    Homologene
    FAMILY
  • amino acid/polyamine transporter 2 family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text extensively accumulated in the cytoplasm of pre-malignant liver and most hepatocellular carcinoma
    basic FUNCTION
  • important transporter of glutamine, an intermediate in the detoxification of ammonia and the production of urea
  • specific role in the uptake of glutamine involved in the generation of the neurotransmitter glutamate in retina
  • its activation confers growth and survival advantages in pre-malignant and malignant liver lesions
  • a key contributor to system A activity at term (System A-mediated amino acid transport across the placenta is important for the supply of neutral amino acids needed for fetal growth)
  • N-glycosylated protein and N-glycosylation of SLC38A1 may play an important role in the transport of substrates across the cell membrane
  • SLC38A1 is an obesity-associated gene in brown adipose tissue (BAT) and a hypoxia-responsive gene in brown adipocytes
  • played an essential role in the development and progression of osteosarcoma
  • SLC38A1 is not merely a transporter accumulating glutamine for metabolic purposes, but a key component regulating several neuronal functions
  • promoted ischemic brain damage via MTOR-autophagy system
  • key role of SLC38A1 for newly formed GABA, in harmony with the existence of a glutamate/GABA-glutamine (GGG) cycle
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MECP2 acts as a microglia-specific transcriptional repressor of SLC38A1
  • cell & other
    REGULATION
    repressed by taurine
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    activated in hepatocellular carcinoma tissues and also elevated in pre-malignant cirrhotic livers compared with normal livers
    tumoral     --over  
    related to an unfavorable prognosis and defective immune infiltration in hepatocellular carcinoma (HCC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may serve as a prognostic and therapeutic marker of OS
  • Therapy target
    ANIMAL & CELL MODELS