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FLASH GENE
Symbol SLC36A1 contributors: mct/npt/pgu - updated : 09-12-2009
HGNC name solute carrier family 36 (proton/amino acid symporter), member 1
HGNC id 18761
Location 5q33.1      Physical location : 150.827.162 - 150.871.939
Genatlas name proton-coupled amino acid transporter 1
Synonym name
  • lysosomal amino-acid transporter 1
  • proton / amino acid symporter
  • Synonym symbol(s) FLJ10815, LYAAT1, PAT1, TRAMD3
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 44.78 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 5821 53 476 - 2009 19549785
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine     Homo sapiensAdult
    Nervousbraindiencephalonhypothalamus  
     brainforebraincerebral cortex  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialabsorptive excretorydigestive epithelium (mucosa)   Homo sapiensAdult
    Nervouscentral   
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveenterocyte Homo sapiensAdult
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • cytosolic N terminal domain (three consensus eleven transmembrane domains, N glycosylation sites)
  • a disulfide bond between Cys-180 and Cys-329 (disulfide bridge linkage of extracellular loop (EL) 2 and EL 4 is therefore essential for transport function but not for membrane localization)
  • two primary functional domains: one promoting translation repression and P-body assembly and a second domain promoting mRNA decapping after assembly of the mRNA into a P-body mRNP
  • RNA binding protein and multidomain protein that functions at multiple stages in the process of translation repression and mRNA decapping
  • HOMOLOGY
    interspecies homolog to murine Viaat
    intraspecies paralog to SLC36A2
    Homologene
    FAMILY
  • AAAP family (amino acid/auxin permease)
  • solute carrier family 36
  • CATEGORY RNA associated , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,lysosome
    text
  • localized mainly to the apical membrane of intestine epithelial cells and is also found in lysosomes in brain neurons
  • basic FUNCTION
  • amino acid transporter involved in the efflux of lysosomal products (Pro-ALa-gly) from the organelles lumen to cytosol
  • RNA binding protein and a multidomain protein that functions at multiple stages in the process of translation repression and mRNA decapping
  • major route by which small neutral amino acids are absorbed after intestinal protein digestion
  • mediates the uptake of small neutral amino acids at the apical membrane of intestinal epithelial cells after protein digestion
  • H(+)-coupled, pH-dependent, Na(+)- and Cl(-)-independent, low-affinity, high-capacity transporter for taurine and beta-alanine
  • may be responsible for bulk taurine uptake during a meal
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • direct interaction with the basolateral sorting signal of APP/APLPs (functional link between APP/APLPs transport and their processing)
  • binds RNA and has numerous domain-specific interactions with mRNA decapping factors
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS