Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

SLC36A1

contributors: mct/npt/pgu - updated : 09-12-2009

HGNC name	solute carrier family 36 (proton/amino acid symporter), member 1
HGNC id	18761

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	5q33.1      Physical location : 150.827.162 - 150.871.939
Genatlas name	proton-coupled amino acid transporter 1
Synonym name	lysosomal amino-acid transporter 1
	proton / amino acid symporter
Synonym symbol(s)	FLJ10815, LYAAT1, PAT1, TRAMD3

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	44.78 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_078483 11 - 5821 NP_510968 53 476 - 2009 19549785

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine         Homo sapiens Adult Nervous brain diencephalon hypothalamus       brain forebrain cerebral cortex

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial absorptive excretory digestive epithelium (mucosa)     Homo sapiens Adult Nervous central       Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Digestive enterocyte Homo sapiens Adult Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	cytosolic N terminal domain (three consensus eleven transmembrane domains, N glycosylation sites)
	a disulfide bond between Cys-180 and Cys-329 (disulfide bridge linkage of extracellular loop (EL) 2 and EL 4 is therefore essential for transport function but not for membrane localization)
	two primary functional domains: one promoting translation repression and P-body assembly and a second domain promoting mRNA decapping after assembly of the mRNA into a P-body mRNP
	RNA binding protein and multidomain protein that functions at multiple stages in the process of translation repression and mRNA decapping

HOMOLOGY

interspecies

homolog to murine Viaat

intraspecies

paralog to SLC36A2

Homologene

FAMILY	AAAP family (amino acid/auxin permease)
	solute carrier family 36

CATEGORY

RNA associated , transport carrier

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,lysosome
text	localized mainly to the apical membrane of intestine epithelial cells and is also found in lysosomes in brain neurons

basic FUNCTION	amino acid transporter involved in the efflux of lysosomal products (Pro-ALa-gly) from the organelles lumen to cytosol
	RNA binding protein and a multidomain protein that functions at multiple stages in the process of translation repression and mRNA decapping
	major route by which small neutral amino acids are absorbed after intestinal protein digestion
	mediates the uptake of small neutral amino acids at the apical membrane of intestinal epithelial cells after protein digestion
	H(+)-coupled, pH-dependent, Na(+)- and Cl(-)-independent, low-affinity, high-capacity transporter for taurine and beta-alanine
	may be responsible for bulk taurine uptake during a meal

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	direct interaction with the basolateral sorting signal of APP/APLPs (functional link between APP/APLPs transport and their processing)
	binds RNA and has numerous domain-specific interactions with mRNA decapping factors

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS