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FLASH GENE
Symbol SLC35G1 contributors: mct - updated : 06-02-2013
HGNC name solute carrier family 35, member G1
HGNC id 26607
Location 10q23.33      Physical location : -
Synonym name
  • transmembrane protein 20
  • partner of STIM1
  • Synonym symbol(s) C10orf60, FLJ33990, TMEM20, POST
    DNA
    TYPE functioning gene
    STRUCTURE 8.76 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2428 - 365 - 2011 22084111
    3 - 2425 - 364 - 2011 22084111
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
    Reproductivemale systemtestis   
    Urinarybladder   highly
    Visualeye    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 10-transmembrane segments
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    text located in the plasma membrane and ER
    basic FUNCTION
  • might modulate ORAI1 activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • formation of the STIM1–SLC35G1 complex with ATP2B1 attenuates Ca2+ pump activity and may sustain cytosolic Ca2+ elevation
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SLC35G1 -ORAI1 binding is store depletion-independent, and not critical for store-operated STIM1-dependent ORAI1 activation
  • is an interacting partner of STIM1 that enables STIM1 binding to multiple transporters
  • inhibits ATP2B1 activity in store-depleted cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS