Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SLC35D1 contributors: mct/npt - updated : 05-12-2009
HGNC name solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1
HGNC id 20800
Corresponding disease
CLSP chondrodysplasia lethal neonatal, with snail-like pelvis
Location 1p31.3      Physical location : 67.465.014 - 67.520.080
Synonym name
  • UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter 7
  • nucleotide sugar transporter
  • UDP-GlcA/UDP-GalNAc transporter
  • Synonym symbol(s) NST, KIAA0260, UGTREL7, MGC138236
    DNA
    TYPE functioning gene
    STRUCTURE 49.88 kb     12 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 6475 - 355 - Gregory (2006), Hiraoka (2007)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen    
     thymus   highly
    Reproductivefemale systemuterus   
     male systemtestis   
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text spleen
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to C.elegans C52E12.3
    Homologene
    FAMILY
  • nucleotide-sugar transporter (TPT) family
  • SLC35D subfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • involved in the UDP-N-acetylgalactosamine transport
  • may participate in glucuronidation and/or chondroitin
  • sulfate biosynthesis
  • regulating the chondroitin sulfate length in cartilage proteoglycan by supplying the nucleotide-sugars used as substrates for chondroitin sulfate biosynthesis
  • nucleotide-sugar transporter (NST) that might transport substrates needed for chondroitin sulfate biosynthesis (Hiraoka 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CLSP
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Slc35d1-deficient mice that develop a lethal form of skeletal dysplasia with severe shortening of limbs and facial structures