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FLASH GENE
Symbol SLC35C2 contributors: mct - updated : 06-05-2011
HGNC name solute carrier family 35, member C2
HGNC id 17117
Location 20q13.12      Physical location : 44.978.177 - 44.993.064
Synonym name
  • chromosome 20 open reading frame 5
  • ovarian cancer overexpressed 1
  • Synonym symbol(s) CGI-15, OVCOV1, C20orf5, FLJ37039, MGC20633, MGC32079, MGC39183
    DNA
    TYPE functioning gene
    STRUCTURE 14.89 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    Physical map
    PTE1 20q12-q13.1 peroxisomal acyl-CoA thioesterase ZSWIM3 20q13.12 zinc finger, SWIM domain containing 3 ZSWIM1 20q13.12 zinc finger, SWIM domain containing 1 C20orf165 20q13.12 chromosome 20 open reading frame 165 C20orf163 20q13.12 chromosome 20 open reading frame 163 PPGB 20q13.1 protective protein for beta-galactosidase (galactosialidosis) PLTP 20q12 phospholipid transfer protein C20orf67 20q13.12 chromosome 20 open reading frame 67 ZNF335 20q11.21-q13.12 zinc finger protein 335 FTLP 20q13.12 ferritin, light polypeptide pseudogene MMP9 20q11.2 matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) LOC128499 20q13.12 hypothetical LOC128499 SLC12A5 20q12-q13.1 solute carrier family 12, (potassium-chloride transporter) member 5 NCOA5 20q12-q13.2 nuclear receptor coactivator 5 RPL13P2 20q13.12 ribosomal protein L13 pseudogene 2 TNFRSF5 20q12-q13.2 tumor necrosis factor receptor superfamily, member 5 CDH22 20q12-q13.1 cadherin-like 22 SLC35C2 20q13.12 solute carrier family 35, member C2 ELMO2 20q13 engulfment and cell motility 2 (ced-12 homolog, C. elegans) DKFZp547G0215 20q13.12 hypothetical protein DKFZp547G0215 MKRNP3 20q21.1 makorin, ring finger protein, pseudogene 3 LOC343593 20q13.12 similar to BC331191_1 ZNF334 20q13.12 zinc finger protein 334 SLC13A3 20q12-q13.1 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 C20orf64 20q13 chromosome 20 open reading frame 64 SLC2A10 20q13.1 solute carrier family 2 (facilitated glucose transporter), member 10
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2266 40.4 365 - 2001 11856893
    differs in the 5' UTR compared to variant 1
    10 - 2203 - 344 - 2001 11856893
    lacks an alternate in-frame segment, compared to variant 1, resulting in a shorter protein
    10 - 2461 - 365 - 2001 11856893
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     stomach    
    Lymphoid/Immunespleen    
    Nervousnervespinal nervesciatic  
    Reproductivefemale systemuteruscervix  
    Skin/Tegumentskin    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Connectivebone   
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage stem cells
    cell lines
    fluid/secretion blood
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one potential N-glycosylation site
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Slc35c2
    ortholog to rattusSlc35c2_predicted
    Homologene
    FAMILY
  • nucleotide-sugar transporter family
  • SLC35C subfamily
  • CATEGORY tumor suppressor , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    text
  • found mostly in the Golgi fraction, although there appeared to be a weak band in the ER fraction
  • basic FUNCTION
  • may be playing an important role in the cellular response to tissue hypoxia
  • suppress alpha(1,3)fucosylation by mechanisms unrelated to effects on fucosyltransferase gene expression
  • factor required for optimal NOTCH1 signaling in mammalian cells
  • either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of NOTCH1 and required for optimal NOTCH1 signaling in mammalian cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by in hypoxic trophoblast cells
    repressed by regulated by oxygen tension
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in ovarian cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS