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FLASH GENE
Symbol SLC35C1 contributors: - updated : 16-01-2006
HGNC name solute carrier family 35, member C1
HGNC id 20197
Corresponding disease
CDG2C congenital disorder of glycosylation type 2C
Location 11p11.2      Physical location : 45.825.622 - 45.834.566
Genatlas name GDP-fucose transporter 1
Synonym symbol(s) FLJ11320, FUCT1
DNA
TYPE functioning gene
STRUCTURE 9.00 kb     3 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   moderately
Digestiveintestinelarge intestinecolon predominantly
 intestinesmall intestine  moderately
 liver   highly
Reproductivefemale systemovary  highly
 female systemplacenta  moderately
Respiratorylung   moderately
Skin/Tegumentskin   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatum   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
  • multiple putative transmembrane domain (10)
  • four transmembrane highly conserved domains
  • HOMOLOGY
    interspecies homolog to Drosophila FUCT1
    ortholog to dog slc35c1
    ortholog to rattus Slc35c1 predicted
    ortholog to murine Slc35c1
    Homologene
    FAMILY
  • nucleotide-sugar transporter family
  • SLC35C subfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • involved in GDP-fucose import from the cytoplasm into the Golgi lumen
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDG2C
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS