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FLASH GENE
Symbol SLC35A2 contributors: mct - updated : 25-05-2014
HGNC name solute carrier family 35 (UDP-galactose transporter), member A2
HGNC id 11022
Corresponding disease
CDG2M congenital disorder of glycosylation, type IIm
Location Xp11.23      Physical location : 48.760.458 - 48.769.235
Synonym name UDP-galactose translocator
Synonym symbol(s) UGTL, UGALT, UGAT, UGT, UGT1, UGT2
DNA
TYPE functioning gene
STRUCTURE 8.78 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1451 - 396 . when overexpressed UGT1, the protein colocalized with the Golgi marker only 2003 12925779
  • UGT1
  • N-terminally epitope tagged forms localize exclusively to the Golgi
  • 4 - 1763 - 242 . when UGT2 was overexpressed, the protein colocalized with the endoplasmic reticulum (ER) marker only 2003 12925779
  • UGT2
  • both ER (endoplasmic reticulum) and Golgi localization
  • dilysine motif KVKGS may be responsible for the dual localization (replacement of KVKGS by the strong ER retention signal KKNT is sufficient to completely retain UGT2 in the ER)
  • 4 - 2619 - 393 - 2003 12925779
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Lymphoid/Immunethymus   highly
    Respiratoryrespiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    ten transmembrane helices
    HOMOLOGY
    Homologene
    FAMILY solute carrier family 35, nucleotide-sugar transporter family
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    basic FUNCTION
  • transporting nucleotide sugars from the cytosol into Golgi vesicles where glycosyltransferases function
  • biological function of SLC35A2 and SLC35A3 in galactosylation of macromolecules may be coupled
  • SLC35A2 and SLC35A3 function in glycosylation is combined via their mutual interaction
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SLC35A2 and SLC35A3 cooperate in the UDP-Gal delivery for glycosyltransferases located in the Golgi apparatus
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDG2M
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional mosaic      
    causes a congenital disorder of glycosylation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS