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FLASH GENE
Symbol SLC35A1 contributors: npt/ - updated : 28-09-2004
HGNC name solute carrier family 35 (CMP-sialic acid transporter), member A1
HGNC id 11021
Corresponding disease
CDG2F congenital disorder of glycosylation, type 2F
Location 6q15      Physical location : 88.182.642 - 88.222.051
Synonym name
  • solute carrier family 35 (UDP-galactose transporter), member 1
  • mutated CMP-sialic acid transporter A1
  • Synonym symbol(s) CST, CMPST, FLJ76955, CMP-Sia-Tr, CMP-SA-Tr
    DNA
    TYPE functioning gene
    STRUCTURE 39.42 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    SNX14 6q15 sorting nexin 14 SYNCRIP 6q14-q15 synaptotagmin binding, cytoplasmic RNA interacting protein LOC389414 6 LOC389414 LOC391949 6 similar to 60S ribosomal protein L7 LOC134686 6q15 similar to NADH-ubiquinone oxidoreductase 13 kDa-B subunit (Complex I-13Kd-B) (CI-13Kd-B) (Complex I subunit B13) HTR1E 6q14-q15 5-hydroxytryptamine (serotonin) receptor 1E CGA 6q12-q21 glycoprotein hormones, alpha polypeptide LOC391950 6 similar to Reticulocalbin 1 precursor LOC389415 6 LOC389415 ZNF292 6q15 zinc finger protein 292 GJB7 6q15 gap junction protein, beta 7 C6orf162 6q15-q16.1 chromosome 6 open reading frame 162 C6orf163 6q15 chromosome 6 open reading frame 163 C6orf165 6q15 chromosome 6 open reading frame 165 TAF13P 6q14.3-15 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, pseudogene SLC35A1 6q16.1 solute carrier family 35 (CMP-sialic acid transporter), member A1 RARSL 6q16.1 arginyl-tRNA synthetase-like ORC3L 6q14.3-16.3 origin recognition complex, subunit 3-like (yeast) C6orf166 6q15 chromosome 6 open reading frame 166 SPACA1 6q16.1 sperm acrosome associated 1 CNR1 6q14-q15 cannabinoid receptor 1 (brain) LOC391951 6 similar to ribosomal protein S14 ACTBP8 6q13 actin, beta pseudogene 8 RNGTT 6q16 RNA guanylyltransferase and 5'-phosphatase HCP16 6q15 cytochrome c, somatic pseudogene PNRC1 6q16.1 proline-rich nuclear receptor coactivator 1 SRrp35 6q16.1 serine-arginine repressor protein (35 kDa) ACY1L2 6q16.1 aminoacylase 1-like 2 GABRR1 6q13-q15.3 gamma-aminobutyric acid (GABA) receptor, rho 1 GABRR2 6q14-q16.3 gamma-aminobutyric acid (GABA) receptor, rho 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1741 - 278 - -
    8 - 1918 - 337 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Slc35a1
    homolog to Drosophila Csat
    homolog to C.elegans ZK370.7
    intraspecies homolog to SLC35A2
    Homologene
    FAMILY
  • nucleotide-sugar transporter family
  • SLC35A subfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • transporting CMP-sialic acid from the cytosol into golgi vescles where glycosyltransferases function
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text CMP-sialic acid transport ; nucleotide-sugar transport
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDG2F
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS