Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SLC34A3 contributors: mct/npt - updated : 11-01-2010
HGNC name solute carrier family 34 (sodium phosphate), member 3
HGNC id 20305
Corresponding disease
HHRH hypophosphatemic ricket with hypercalciuria, hereditary
Location 9q34.3      Physical location : 140.125.208 - 140.131.006
Synonym name
  • type IIc Na+/Pi cotransporter
  • sodium/phosphate cotransporter 2C
  • Na(+)-dependent phosphate cotransporter 2C
  • Synonym symbol(s) NPTIIc, FLJ38680, NAPI-IIc, NPT2c, NAPI-2C
    DNA
    TYPE functioning gene
    STRUCTURE 5.62 kb     13 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 2142 - 599 - Forster (2006)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Urinarykidneytubuleconvoluted tubule  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Urinaryepithelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • SLC34A transporter family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • having a sodium-dependent phosphate transporter activity
  • playing a key role in the regulation of phosphate homeostasis
  • with SLC34A1, play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development (Segawa 2009)
  • wth SLC34A1 play important roles in the regulation of phosphate homeostasis (Iwaki 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • direct interaction between SLC34A3 and PDZK1 seems to play an important role in the physiological regulation of SLC34A3
  • cell & other
    REGULATION
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION     plasma membrane
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HHRH
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS