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FLASH GENE
Symbol SLC31A2 contributors: mct/npt - updated : 22-12-2009
HGNC name solute carrier family 31 (copper transporters), member 2
HGNC id 11017
Location 9q32      Physical location : 115.913.237 - 115.926.421
Synonym name copper transporter 2
Synonym symbol(s) CTR2, COPT2
DNA
TYPE functioning gene
STRUCTURE 13.18 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
EPF5 9q33.1 EPF5 pseudogene LOC392384 9 similar to 60S ribosomal protein L32 MGC10940 9q33.1 hypothetical protein MGC10940 LOC389784 9 LOC389784 KIAA1958 9q33.1 KIAA1958 HSPC043 LOC389785 9 similar to RIKEN cDNA 4732481H14 LOC169831 9q33.1 similar to RIKEN cDNA 4732481H14 TSCOT 6p21-p11.2 thymic stromal co-transporter LOC169834 9q33.1 hypothetical protein LOC169834 ZFP37 9q32 zinc finger protein 37 homolog (mouse) SLC31A2 9q31-q32 solute carrier family 31 (copper transporters), member 2 SLC31A1 9q31-q32 solute carrier family 31 (copper transporters), member 1 CDC26 9q32 cell division cycle 26 PRPF4 9q31-q33 PRP4 pre-mRNA processing factor 4 homolog (yeast) MGC4734 9q33.1 hypothetical protein MGC4734 WDR31 9q33.1 WD repeat domain 31 BSPRY 9q33.1 B-box and SPRY domain containing MGC12904 9q33.1 hypothetical protein MGC12904 ALAD 9q33.3 aminolevulinate, delta-, dehydratase POLE3 9q33 polymerase (DNA directed), epsilon 3 (p17 subunit) C9orf43 9q33.1 chromosome 9 open reading frame 43 RGS3 9q31-q33 regulator of G-protein signalling 3 FLJ31713 9q33.1 hypothetical protein FLJ31713 LOC392385 9 similar to programmed cell death 2 isoform 1; zinc finger protein Rp-8; programmed cell death 2/Rp8 homolog
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 splicing 1791 - 143 - Zhou (1997)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • transmembrane protein with extracellular metal binding site
  • HOMOLOGY
    interspecies homolog to yeast ctr2
    Homologene
    FAMILY
  • SLC31A transporter family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • promotes copper uptake at the plasma membrane (Bertinato 2008)
  • localized in late endosomes and lysosomes (van den Berghe 2007)
  • basic FUNCTION
  • mediate the uptake of Cu(+1) by mammalian cells (Blair 2009)
  • regulates the cellular accumulation and cytotoxicity of cisplatin and carboplatin (Blair 2009)
  • promotes copper uptake at the plasma membrane and plays a role in regulating copper levels (Bertinato 2008)
  • oligomeric membrane protein localized in lysosomes, which stimulates copper delivery to the cytosol of human cells at relatively high copper concentrations (van den Berghe 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS