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FLASH GENE
Symbol SLC30A10 contributors: mct - updated : 06-02-2018
HGNC name solute carrier family 30, member 10
HGNC id 25355
Corresponding disease
CDPH Hepatic Cirrhosis, Dystonia, Polycythemia, and Hypermanganesemia
Location 1q41      Physical location : 220.087.606 - 220.101.993
Synonym name
  • zinc transporter 8
  • zinc transporter 10
  • solute carrier family 30 (zinc transporter), member 10
  • Synonym symbol(s) ZNT8, ZnT-10, ZNT10, DKFZp547M236, HMDPC, HMNDYT1, ZRC1
    DNA
    TYPE functioning gene
    STRUCTURE 14.39 kb     4 Exon(s)
    regulatory sequence Promoter
    Binding site   metal/iron
    text structure
  • ZTRE in the 5&
  • 8242;-UTR of the SLC30A10 gene that is functional in a promoter-reporter construct
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2869 - 485 - 2016 27307044
    - - 2907 - 223 - 2016 27307044
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine    Homo sapiens
     liver     Homo sapiens
    Nervousbrainbasal nuclei  highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six transmembrane helices (TMD IVI) with both N and C termini located on the cytoplasmic side of the plasma membrane
  • AAs in the transmembrane and C-terminal domains together confer optimal manganese transport capability to SLC30A10
  • HOMOLOGY
    Homologene
    FAMILY
  • cation diffusion facilitator (CDF) family of metal ion transporters
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • involved in intracellular zinc homeostasis
  • functions as a Mn transporter and, when defective, causes Mn accumulation in liver and brain
  • SLC30A10 is critical for zinc and manganese homeostasis
  • is a cell surface-localized manganese efflux transporter
  • SLC30A10 and SLC39A14 are manganese efflux and influx transporters, respectively
  • transport activities of both SLC39A14 and SLC30A10 are required for hepatic manganese excretion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • vitamin D3 transactivates the SLC30A10 gene in a VDR-dependent manner, resulting in increased ZNT10 protein expression
  • cell & other
    REGULATION
    activated by SERPINF1 in RPE
    ASSOCIATED DISORDERS
    corresponding disease(s) CDPH
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    hypothyroidism induced by loss of SLC30A10 may be explained by reduced thyroxine production
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS