Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SLC30A10 contributors: mct - updated : 14-03-2012
HGNC name solute carrier family 30, member 10
HGNC id 25355
Corresponding disease
CDPH Hepatic Cirrhosis, Dystonia, Polycythemia, and Hypermanganesemia
Location 1q41      Physical location : 220.087.606 - 220.101.993
Synonym name
  • zinc transporter 8
  • zinc transporter 10
  • solute carrier family 30 (zinc transporter), member 10
    • Synonym symbol(s) ZNT8, ZnT-10, ZNT10, DKFZp547M236
    DNA
    TYPE functioning gene
    STRUCTURE 14.39 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2869 - 485 - 2004 15154973
    - - 2907 - 223 - 2004 15154973
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver     Homo sapiens
    Nervousbrainbasal nuclei  highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six transmembrane helices (TMD I–VI) with both N and C termini located on the cytoplasmic side of the plasma membrane
    • HOMOLOGY
    Homologene
    FAMILY
  • cation diffusion facilitator (CDF) family of metal ion transporters
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • involved in intracellular zinc homeostasis
  • functions as a Mn transporter and, when defective, causes Mn accumulation in liver and brain
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by SERPINF1 in RPE
    ASSOCIATED DISORDERS
    corresponding disease(s) CDPH
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS