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FLASH GENE
Symbol SLC2A2 contributors: mct - updated : 28-05-2014
HGNC name solute carrier family 2 (facilitated glucose transporter), member 2
HGNC id 11006
Corresponding disease
FBIS Fanconi-Bickel syndrome
Location 3q26.2      Physical location : 170.714.136 - 170.744.768
Synonym name
  • glucose transporter type 2, liver
  • Synonym symbol(s) GLUT2, GTR2
    DNA
    TYPE functioning gene
    STRUCTURE 30.63 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC389175 3 similar to ribosomal protein L22 LOC285262 3q26.31 similar to Succinate dehydrogenase [ubiquinone] cytochrome B small subunit, mitochondrial precursor (CybS) (Succinate-ubiquinone reductase membrane anchor subunit) (QPS2) (CII-4) (Succinate dehydrogenase complex subunit D) (Succinat TERC 3q26 telomerase RNA component ARPM1 3q26.31 actin related protein M1 MYNN 3p21.3-q25.2 myoneurin MGC27085 3q26.31 hypothetical protein MGC27085 LOC344657 3q26.31 similar to RIKEN cDNA 4930558O21 FLJ23259 3q26.31 hypothetical protein FLJ23259 LOC151825 3q26.31 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) SAMD7 3q26.31 sterile alpha motif domain containing 7 TLOC1 3q26.2-q27 translocation protein 1 FLJ32803 3q26.31 hypothetical protein FLJ32803 GPR160 3q26.2-q27 G protein-coupled receptor 160 LOC389176 3 similar to Histone-lysine N-methyltransferase, H4 lysine-20 specific (Histone H4-K20 methyltransferase) (H4-K20-HMTase) (SET domain-containing protein 8) (PR/SET domain-containing protein 07) (PR/SET07) (PR-Set7) PHC3 3q26.32 polyhomeotic like 3 (Drosophila) PRKCI 3q26.3 protein kinase C, iota SKIL 3q26 SKI-like CLDN11 3q26.2-q26.3 claudin 11 (oligodendrocyte transmembrane protein) FLJ37228 3q26.31 hypothetical protein FLJ37228 KIAA1613 3q26.31 KIAA1613 protein LOC391591 3 similar to ribosomal protein L28; 60S ribosomal protein L28 LOC200916 3q26.31 similar to RIKEN cDNA 3110001N18 EIF5A2 3q25-q27 eukaryotic translation initiation factor 5A2 SLC2A2 3q26.2-q26.3 solute carrier family 2 (facilitated glucose transporter), member 2 KIAA0551 3q26.31 Traf2 and NCK interacting kinase PLD1 3q26 phospholipase D1, phophatidylcholine-specific LOC389177 3 LOC389177 FAD104 3q26.31 FAD104 LOC391592 3 similar to basic leucine zipper and W2 domains 1 GHSR 3q26.2 growth hormone secretagogue receptor TNFSF10 3q26 tumor necrosis factor (ligand) superfamily, member 10
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 3176 - 405 - 2002 12135767
    10 - 3314 - 351 - 2002 12135767
    11 - 3439 - 524 - 2002 12135767
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly Homo sapiens
    Endocrinepancreas   predominantly Homo sapiens
    Urinarykidney   highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
     epithelial cell
    Endocrineislet cell (alpha,beta...) Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • twelve putative transmembrane segments (12TM)
  • intracellular N and C termini
  • a large extracellular loop with a glycosylation site between TM1 and 2
  • a small and a large intracellular loops,respectively between TM2 and 3 and TM8 and 9,both with the conserved RXGRR motif
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Slc2a2
    Homologene
    FAMILY solute carrier family 2 (sugar transporter family), glucose transporter subfamily
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text basolateral membrane
    basic FUNCTION
  • facilitated glucose transporter, involved in glucosamine transport
  • is responsible for uptake of glucose by the beta cells
  • may comprise part of the glucose-sensing mechanism of the beta cell
  • may also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney
  • functions as part of the glucose sensing mechanism for the stimulation of insulin secretion (pMID: 19477941)
  • is unlikely to be the principal glucose transporter in human beta-cells
  • important role of SLC2A2 transporter fueling metabolism at body level
  • role important during embryonic period for differentiation of insulin-producing cells and insulin secretion
  • having functions in pancreatic beta cell development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • hyperglycemia directly affects beta-cell function and activates a trafficking pathway that results in the rapid endocytosis and degradation of the cell surface SLC2A2 glucose transporter
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) FBIS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation     loss of function
    biallelic SLC2A2 inactivation causes lethal neonatal diabetes
    Susceptibility
    Variant & Polymorphism SNP
  • are associated with the conversion from impaired glucose tolerance to type 2 diabetes
  • polymorphisms at positions -269, -44, or + 103 may affect GLUT2 gene transcription, possibly associated with reduced expression of the GLUT2 gene in NIDDM patients
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    homozygous mice deficient in GLUT2 are hyperglycemic and relatively hypoinsulinemic and have elevated plasma levels of glucagon, free fatty acids, and beta-hydroxybutyrate