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FLASH GENE
Symbol SLC2A11 contributors: - updated : 06-06-2007
HGNC name solute carrier family 2 (facilitated glucose transporter), member 11
HGNC id 14239
Location 22q11.2      Physical location : 24.199.058 - 24.227.723
Synonym name
  • glucose transporter protein 10
  • glucose transporter protein 11
  • glucose transporter-like protein XI
  • facilitative glucose transporter GLUT11-a
  • facilitative glucose transporter GLUT11-c
  • Synonym symbol(s) GLUT11, GLUT10, GT11
    DNA
    TYPE functioning gene
    STRUCTURE 28.00 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    RTDR1 22q11.2 rhabdoid tumor deletion region gene 1 GNAZ 22q11.22 guanine nucleotide binding protein (G protein), alpha z polypeptide RAB36 22q11.2 RAB36, member RAS oncogene family BCR 22q11.23 breakpoint cluster region FBXW3 22q11 F-box and WD-40 domain protein 3 LOC343851 22q11.23 similar to hypothetical protein FLJ31547 FLJ31568 22q11.23 hypothetical protein FLJ31568 LOC388882 22 hypothetical gene supported by BC036910 LOC388883 22 similar to Gag-Pro-Pol protein IGLL1 22q11.22 immunoglobulin lambda-like polypeptide 1 LOC391321 22 similar to Rhabdoid tumor deletion region protein 1 LOC51233 22q11.2 hypothetical protein LOC51233 LOC388884 22 similar to Immunoglobulin lambda-like polypeptide 1 precursor (Immunoglobulin-related 14.1 protein) (Immunoglobulin omega polypeptide) (Lambda 5) (CD179b antigen) ASLL 22q11.22 argininosuccinate lyase-like Rgr 22q11.23 Ral-GDS related protein Rgr ZNF70 22q11.22 zinc finger protein 70 (Cos17) VPREB3 22q11.2 pre-B lymphocyte gene 3 FLJ36561 22q11.23 hypothetical protein FLJ36561 MMP11 22q11.22 matrix metalloproteinase 11 (stromelysin 3) SMARCB1 22q11.23 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 FLJ43842 22q11.23 FLJ43842 protein SLC2A11 22q11.2 solute carrier family 2 (facilitated glucose transporter), member 11 MIF 22q11.22 macrophage migration inhibitory factor (glycosylation-inhibiting factor) LOC284890 22q11.23 similar to lymphocyte activation-associated protein; kelch (Drosophila)-like 5 DDT 22q11.23 D-dopachrome tautomerase GSTT2 22q11.23 glutathione S-transferase theta 2 HS322B1A 22q12 hypothetical protein HS322B1A LOC391322 22 similar to D-dopachrome tautomerase (Phenylpyruvate tautomerase II) GSTT1 22q11.23 glutathione S-transferase theta 1 LOC343854 22q11.23 similar to RIKEN cDNA 4930583C14 CABIN1 22q11.2-q12.3 similar to RIKEN cDNA 4930583C14 BK65A6.2 GGTLA1 22q11.2 gamma-glutamyltransferase-like activity 1 LOC339661 22q11.23 similar to Gamma-glutamyltransferase-like protein 4 DKFZP434P211 22q11.22 POM121-like protein LOC388885 22 LOC388885 KIAA0376 22q11.2-q12.3 LOC388885 ADORA2A 22q11.22 adenosine A2a receptor UPB1 22q11.2 ureidopropionase, beta MGC1842 22q11.2 hypothetical protein MGC1842 SNRPD3 22q11.21 small nuclear ribonucleoprotein D3 polypeptide 18kDa GGT1 22q11.23 gamma-glutamyltransferase 1 LOC388886 22 similar to hypothetical protein LOC192734
    RNA
    TRANSCRIPTS type messenger
    text different promoters and splicing of the human SLC2A11 gene generate three GLUT11 isoforms which are expressed in a tissue specific manner but do not appear to differ in their functional characteristics
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 1600 42 496 in adipose tissue, heart, skeletal muscle, and pancreas Wu, Scheepers
  • ubiquitous but not liver
  • lacking 2 exons
  • - splicing 2050 - 503 liver, brain, lung, trachea, heart, skeletal muscle, and kidney Wu, Scheepers
    - - 1590 - 499 in kidney, adipose tissue, and placenta Scheepers
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver    
    Endocrinepancreas    
    Nervousnervecranial nerve  highly
     nervespinal nervesciatic  
    Reproductivefemale systemplacenta  highly
    Visualeyeanterior segment   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebonesubchondral  
    Epithelialsensory   
    Muscularstriatumskeletal  
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousoptic nerve
    cell lineage
    cell lines hepatocellular carcinoma cell line
    fluid/secretion
    at STAGE
    physiological period fetal
    Text eye, placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    twelve putative membrane spanning helices
    HOMOLOGY
    interspecies homolog to C.elegans Lin-11
    intraspecies homolog to GLUTS
    Homologene
    FAMILY
  • sugar transporter family
  • glucose transporter subfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION facilitative glucose transporter,involved in cell-mediated immunity, immunoregulation, and inflammation.
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by fructose
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS