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FLASH GENE

Symbol

SLC2A11

contributors: mct - updated : 18-03-2020

HGNC name	solute carrier family 2 (facilitated glucose transporter), member 11
HGNC id	14239

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	22q11.23      Physical location : 24.199.058 - 24.227.723
Synonym name	glucose transporter protein 10
	glucose transporter protein 11
	glucose transporter-like protein XI
	facilitative glucose transporter GLUT11-a
	facilitative glucose transporter GLUT11-c
Synonym symbol(s)	GLUT11, GLUT10, GT11, FLJ30961, MGC118830, MGC118833

DNA

TYPE	functioning gene
STRUCTURE	29.61 kb     13 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

text	different promoters and splicing of the human SLC2A11 gene generate three GLUT11 isoforms which are expressed in a tissue specific manner but do not appear to differ in their functional characteristics

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_030807 13 splicing 3102 NP_110434 - 503 liver, brain, lung, trachea, heart, skeletal muscle, and kidney 2005 16154905 GLUT11L or GLUT11A NM_001024938 12 splicing 2991 NP_001020109 - 496 in adipose tissue, heart, skeletal muscle, and pancreas 2005 16154905 GLUT11S, or GLU11C NM_001282864 11 splicing 3264 NP_001269793 - 535 - 2005 16154905 NM_001024939 12 splicing 3088 NP_001020110 - 499 in kidney, adipose tissue, and placenta 2005 16154905 variant 2 or GLUT11B

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive liver         Endocrine pancreas         Nervous nerve cranial nerve     highly   nerve spinal nerve sciatic     Reproductive female system placenta     highly Visual eye anterior segment

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone subchondral     Epithelial sensory       Muscular striatum skeletal     Homo sapiens Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous optic nerve

cell lineage
cell lines	hepatocellular carcinoma cell line
fluid/secretion

at STAGE

physiological period

fetal

Text	eye, placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	twelve putative membrane spanning helices
	a highly conserved hydrophobic motif in the exofacial vestibule of fructose transporting SLC2A proteins (and SLC2A11) acts as a critical determinant of their substrate selectivity

HOMOLOGY

interspecies

homolog to C.elegans Lin-11

intraspecies

homolog to GLUTS

Homologene

FAMILY	sugar transporter family
	glucose transporter subfamily

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	plasma membrane,junction
	intracellular
	intracellular,nucleus,nucleoplasm
text	expressed exclusively in slow-twitch muscle fibres and is unaffected by physiological and pathophysiological conditions except in primary myopathy

basic FUNCTION	facilitative glucose transporter,involved in cell-mediated immunity, immunoregulation, and inflammation
	activities of the enigmatic transporters SLC2A8 and SLC2A11 are required for proliferation and viability in myeloma, albeit because of functionalities probably distinct from whole-cell glucose supply

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

facilitated diffusion transport

PATHWAY

metabolism

carbohydrate

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

inhibited by

fructose

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     therapeutic strategy entailing selective SLC2A4, SLC2A11, SLC2A8 inhibition to specifically target aberrant glucose metabolism in cancer

ANIMAL & CELL MODELS