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FLASH GENE
Symbol SLC29A1 contributors: mct - updated : 17-04-2010
HGNC name solute carrier family 29 (nucleoside transporters), member 1
HGNC id 11003
Location 6p21.1      Physical location : 44.187.241 - 44.201.888
Synonym name
  • equilibrative nitrobenzylmercaptopurine riboside-sensitive
    • nucleoside transporter
  • nucleoside transporter, es-type
    • Synonym symbol(s) ENT1, MGC1465, MGC3778
    DNA
    TYPE functioning gene
    STRUCTURE 14.65 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    POLH 6p21.1-p12 polymerase (DNA directed), eta GTPBP2 6p21-p12 GTP binding protein 2 MAD2L1BP 6p21.1 MAD2L1 binding protein C6orf206 6p21.1 chromosome 6 open reading frame 205 MRPS18A 6p21.3 mitochondrial ribosomal protein S18A VEGF 6p12 vascular endothelial growth factor LOC389392 6 LOC389392 MGC45491 6p21.1 hypothetical protein MGC45491 LOC391921 6 similar to 60S ribosomal protein L29 (Cell surface heparin binding protein HIP) MRPL14 6p21.3 mitochondrial ribosomal protein L14 C6orf110 6p21.1 chromosome 6 open reading frame 110 CAPN11 6p12 calpain 11 LOC389393 6 LOC389393 SLC29A1 6p21.2-p21.1 solute carrier family 29 (nucleoside transporters), member 1 HSPCB 6p12 heat shock 90kDa protein 1, beta SLC35B2 6p12.1-p11.2 solute carrier family 35, member B2 NFKBIE 6p21.1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon LOC391922 6 similar to hypothetical protein MGC33486 MGC33600 6p21.1 hypothetical protein MGC33600 AARSL 6p21.1 alanyl-tRNA synthetase like SPATS1 6p21.1 spermatogenesis associated, serine-rich 1 CDC5L 6p21 CDC5 cell division cycle 5-like (S. pombe) SUPT3H 6p21.3-p21.1 suppressor of Ty 3 homolog (S. cerevisiae)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 2344 - 6 - 1997 9396714
    14 - 2253 - 456 - 1997 9396714
    13 - 2146 - 456 - 1997 9396714
    14 - 2503 - 456 - 1997 9396714
    13 - 2341 - 456 - 1997 9396714
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Nervousbrain    
    Reproductivefemale systembreast   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Epithelialsecretoryglandular  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticerthrocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text liver, spleen
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • highly conserved triplet (PWN) near the N-terminus (mutation of the proline within the PWN motif disrupts plasma membrane localization)
    • HOMOLOGY
    interspecies homolog to murine Slc29a1
    intraspecies homolog to SLC29A2
    Homologene
    FAMILY
  • SLC29A transporter family
    • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • integral membrane protein that transports nucleosides and analog drugs across cellular membranes
  • its expression affects dynamic changes in endogenous adenosine levels, as revealed by altered behavioral responses to drugs that affect adenosine receptor signaling
  • prominent nucleoside transporters which are responsible for antitumor nucleoside uptake
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text nucleoside transporter
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in tumor tissues
    tumoral     --over  
    in lung cancer cell
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS