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FLASH GENE
Symbol SLC28A3 contributors: mct - updated : 07-04-2020
HGNC name solute carrier family 28 (sodium-coupled nucleoside transporter), member 3
HGNC id 16484
Location 9q21.32      Physical location : 86.893.091 - 86.983.413
Synonym name
  • concentrative Na+ nucleoside cotransporter 3
  • solute carrier family 28
  • Synonym symbol(s) CNT3
    DNA
    TYPE like-sequence
    STRUCTURE 95.61 kb     19 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site   HRE
    text structure phorbol myristate acetate response element
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 5158 - 691 - 2018 30096006
    18 - 4962 - 691 - 2018 30096006
    - - - - 622 is retained in the endoplasmic reticulum 2009 18827020
  • insertion of 176 bp corresponding to an intron located between exons 2 and 3
  • lacking 69 residues of the N terminus
  • exhibits a shorter half-life than its plasma membrane counterpart, being degraded via a proteasome-dependent pathway
  • would be involved in the salvage of intracellular nucleosides from the lumen of the endoplasmic reticulum to the cytoplasm
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth    
    Hearing/Equilibriumearinnercochlea   Mus musculus
    Reproductivefemale systembreastmammary gland  
    Respiratoryrespiratory tracttrachea   
    Urinarybladder    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminus of SLC28A3 contains critical motifs implicated in trafficking
  • thirteen putative tramsmembrane helices
  • has two cation-binding sites, one of which is Na+-specific and one of which also accepts H+
  • C-terminal intramembranous cysteine residue of hCNT3 (Cys-561) that reversibly binds the hydrophilic thiol-reactive reagent p-chloromercuribenzene sulfonate (PCMBS)
  • HOMOLOGY
    interspecies homolog to murine Slc28a3
    Homologene
    FAMILY
  • SLC28A transporter family
  • concentrative nucleoside transporter (CNT) protein family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • mediate inwardly-directed Na(+)/nucleoside cotransport, being broadly selective for both pyrimidine and purine nucleosides
  • transporting a broad range of physiological purine and pyrimidine nucleosides as well as anticancer and antiviral nucleoside drugs
  • mediates transport of a broad range of purine and pyrimidine nucleosides and nucleoside drugs
  • is also capable of H(+)-mediated nucleoside cotransport
  • uses the electrochemical gradient of Na(+) and H(+) to drive the transport of nucleosides and therapeutic nucleoside analogs into the cells
  • broad-selectivity, high-affinity protein implicated in the uptake of most nucleoside-derived anticancer and antiviral drugs
  • thought to concentrate nucleosides including cytidine, uridine, adenosine and guanosine in a cell by coupling translocation of two H+ or Na+ ions per nucleoside
  • is directly involved in the metabolism of two drugs (anthracycline and gemcitabine)
  • likely specific role in the sensory epithelium of the utricle and cochlea
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LGALS4 interacts with the drug transporter SLC28A3 to regulate its function
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    increases during gestation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS