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FLASH GENE
Symbol SLC28A1 contributors: mct - updated : 15-04-2020
HGNC name solute carrier family 28 (sodium-coupled nucleoside transporter), member 1
HGNC id 11001
Corresponding disease
URCTU Uridine-cytidineuria
Location 15q25.3      Physical location : 85.427.912 - 85.489.026
Synonym name
  • concentrative nucleoside transporter 1
  • na(+)/nucleoside cotransporter 1
  • sodium-coupled nucleoside transporter 1
  • Synonym symbol(s) CNT1, HCNT1, URCTU
    DNA
    TYPE functioning gene
    STRUCTURE 91.30 kb     19 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    text structure
  • three putative binding sites for the nuclear receptor hepatocyte nuclear factor-4alpha (HNF4A) within the SLC28A1 promoter
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 2750 - 649 - 2013 23722537
    7 - 1339 - 175 - 2013 23722537
    15 - 2155 - 483 - 2013 23722537
    19 - 2241 - 636 - 2013 23722537
    18 - 2654 - 649 - 2013 23722537
    18 - 2041 - 543 - 2013 23722537
    - splicing - - - small intestine, kidney and liver 2019 31440421
  • overexpressed in some cancer tissues relative to normal tissues, particularly kidney, liver and pancreatic cancers
  • a 734-base pair sequence in the fourth intron of the hCNT1 gene was spliced between exons 3 and 4, while exons 5, 13 and part of exon 6 were skipped
  • may serve as a potential cancer biomarker
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine    Homo sapiens
     liver     Homo sapiens
    Lymphoid/Immunelymph node   lowly
    Urinarykidney   highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Slc28a2
    intraspecies homolog to SLC28A2
    Homologene
    FAMILY
  • SLC28A family of transporter
  • concentrative nucleoside transporter (CNT) (TC 2.A.41) family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • renal reabsorption transporter of physiological nucleosides, pyrimidines, adenosin and drugs
  • concentrative nucleoside transporter, sodium dependent
  • mediating the cellular uptake of naturally occurring pyrimidine nucleosides and many structurally diverse anticancer and antiviral nucleoside analogs
  • SLC28A1, SLC28A2 are pyrimidine and purine nucleoside-selective, respectively
  • mediates the uptake of naturally occurring pyrimidine nucleosides, but also nucleoside analogs used in anticancer and antiviral therapy
  • fits the profile of a transceptor in a substrate translocation-independent manner and is likely to be relevant to tumor biology
  • is implicated in sensitizing solid tumors to nucleoside analogs
  • is a putative determinant for nucleoside analog chemoresistance in ovarian cancer
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text nucleoside transporter
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) URCTU
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in lung cancer cell (Hubeek 2008)
    tumoral     --low  
    in tumor cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • as a potential candidate to render drug-resistant pancreatic cancer cells amenable to chemotherapy
  • Marker
    Therapy target
    ANIMAL & CELL MODELS