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FLASH GENE

Symbol

SLC27A4

contributors: mct/npt/pgu - updated : 11-01-2017

HGNC name	solute carrier family 27 (fatty acid transporter), member 4
HGNC id	10998

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	IPS1 ichthyosis prematurity syndrome 1
Location	9q34.11      Physical location : 131.102.838 - 131.123.748
Synonym name	fatty acid transport protein 4
	very long-chain acyl-CoA synthetase 5
Synonym symbol(s)	FATP4, ACSVL4
EC.number	6.2.1.-

DNA

TYPE	functioning gene
STRUCTURE	20.66 kb     13 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005094 13 - 2991 NP_005085 72 643 - 2007 17901542

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine       Skin/Tegument skin

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose       Epithelial barrier lining epidermis

cells

System Cell Pubmed Species Stage Rna symbol   adipocyte Digestive enterocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a transmembrane sequence in the N terminal region
	an AMP binding domain
	an ER localization signal (ERx)

HOMOLOGY

Homologene

FAMILY

ATP-dependent AMP-binding enzyme family

CATEGORY

regulatory , transport carrier

SUBCELLULAR LOCALIZATION	plasma membrane
text	apical side of enterocytes

basic FUNCTION	plays a role in acquired obesity
	principal fatty acid transporter in enterocytes
	playing an important role for skin barrier function
	even though hypoxia regulates the expression of SLC27A2 and SLC27A4 in trophoblasts

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

facilitated diffusion transport

PATHWAY

metabolism

lipid/lipoprotein

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

IPS1

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed digestive liver   potential target for treatment of nonalcoholic fatty liver disease (NAFLD) or steatohepatitis (NASH)

ANIMAL & CELL MODELS