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FLASH GENE
Symbol SLC26A6 contributors: mct - updated : 01-07-2016
HGNC name solute carrier family 26, member 6
HGNC id 14472
Location 3p21.31      Physical location : 48.663.157 - 48.672.926
Synonym name
  • pendrin-like protein 1
  • sulfate anion transporter
  • pendrin L1
  • Synonym symbol(s) CFEX, DKFZp586E1422
    DNA
    TYPE functioning gene
    STRUCTURE 9.77 kb     21 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 polyA site 2750 82.9 738 - 2001 11247665
    also called S+Q
    21 polyA site 2662 - 759 - -
    21 - 2659 - 758 - -
    also called L-Q
    20 - 2605 - 740 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivestomach   highly
    Endocrinepancreas    
    Nervousnervecranial nerve  highly
    Reproductivefemale systemovary  highly
    UrinarykidneytubuleHenles loop   Homo sapiens
     kidneytubuleconvoluted tubule   Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    digestivepancreas
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N and C cytoplasmic termini
  • twelve transmembrane segments (12TM)
  • a large cytoplasmic tail with a sulfate transporter motif and a relatively hydrophobic region near the C terminus
  • the STAS domain (sulfate transporter and anti-sigma factor antagonist)
  • HOMOLOGY
    Homologene
    FAMILY
  • anion transporter family
  • solute carrier 26 family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text apical surface
    basic FUNCTION
  • luminal anion exchanger, mediating electroneutral Cl(-)/HCO(3)(-) exchange
  • fructose-induced hypertension is likely caused by increased salt absorption by the intestine and kidney and the transporters SLC26A6 and SLC2A5 are essential in this process
  • SLC26A1, SLC26A6 and SLC26A7 are novel participants in the extracellular transport of bicarbonate during enamel maturation, and that their functional roles may be achieved by forming interaction units with CFTR (pMID: 26671068)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding the second PDZ domains of the Na(+)/H(+) exchanger kinase and regulatory proteins
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS