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FLASH GENE
Symbol SLC26A3 contributors: mct - updated : 05-06-2012
HGNC name solute carrier family 26, member 3
HGNC id 3018
Corresponding disease
BSND5 Bartter syndrome
CLD chloride diarrhea, familial
Location 7q31.1      Physical location : 107.405.911 - 107.443.678
Synonym name down-regulated in adenoma
Synonym symbol(s) DRA, CLD
DNA
TYPE functioning gene
STRUCTURE 37.77 kb     21 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
regionally located tightly linked to SLC26A4
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
21 - 2894 84.5 764 - 2006 16715296
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestineileum  
 intestinelarge intestinecolon  
Reproductivemale systemseminal vesicles   
 male systemprostate   
Skin/Tegumentskin appendagesskin glandsweat glandeccrine sweat gland 
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialabsorptive excretorydigestive epithelium  
Epithelialbarrier/lininguroepithelium  
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatid
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text highly in placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N and C cytoplasmic terminus
  • twelve transmembrane segments (12TM)
  • a large cytoplasmic tail with a sulfate transporter motif
  • a relatively hydrophobic region near the C terminus, the STAS domain (sulfate transporter) homologous to the bacterial anti-sigma-factor antagonists
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus Sat-1,strongly
    Homologene
    FAMILY solute carrier family 26,sulfate
    CATEGORY tumor suppressor , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text apical brush border
    basic FUNCTION
  • Na+/sulfate cotransporter DIDs resistant from high endothelial venules
  • regulator of body acid-base balance through chloride absorption and bicarbonate excretion in the gut
  • also sulfate and oxalate transporter, sodium independent
  • playing a primary role in male reproduction
  • Cl(-)/HCO(3)(-) exchanger that plays a major role in Cl(-) absorption from the intestine
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by IFNG (involvement of STAT1 in the inhibition of SLC26A3 gene expression by IFN-gamma in the human intestine)
    Other N-glycosylation of SLC26A3 is important for cell surface expression and for protection from proteolytic degradation that may contribute to the understanding of pathogenesis of congenital disorders of glycosylation
    ASSOCIATED DISORDERS
    corresponding disease(s) CLD , BSND5
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in colon adenoma and adenocarcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS