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FLASH GENE
Symbol SLC25A6 contributors: mct - updated : 31-03-2020
HGNC name solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
HGNC id 10992
Location Xp22.33      Physical location : 1.455.044 - 1.511.039
Synonym name
  • adenine nucleotide translocator 3
  • ADP/ATP translocase,X-linked
  • adenine nucleotide translocator 3 (liver)
  • epididymis secretory sperm binding protein
  • Synonym symbol(s) ANT3X, MGC17525, ANT3
    DNA
    TYPE functioning gene
    STRUCTURE 5.96 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    text liver isoform
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1451 - 298 - 1993 8486369
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
     salivary gland   highly
    Reproductivefemale systemuteruscervix highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose   
    cell lineage
    cell lines
    fluid/secretion lymph
    at STAGE
    physiological period embryo
    Text tissue
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three tandemly repeated mitochondrial carrier protein domains
  • three Solcar repeats
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to chicken slc25a5
    Homologene
    FAMILY mitochondrial carrier family
    CATEGORY enzyme , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    basic FUNCTION
  • adenine nucleotide translocator 3, ADP/ATP translocase
  • has a potential role in Th cell survival and immune cell homeostasis
  • is believed to be a component or a regulatory component of the mitochondrial permeability transition pore (mtPTP), which controls mitochondrial permeability transition during apoptosis
  • plays a contributive role in camptothecin (CPT)-induced apoptosis through induction of mitochondrial permeability transition pore (MPTP)
  • export the ATP produced by oxidative phosphorylation (OxPhos) from the mitochondria into the cytosol while importing ADP
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS mitochondrial transport
    PATHWAY
    metabolism energetic
    signaling
    a component
  • component of oxidative phosphorylation (OXPHOS)
  • complexing with cyclophilin D (PPID) and adenine nucleotide translocases (SLC25A4, SLC25A5) at the inner mitochondrial permeability transition pore
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SLC25A6 is a previously unknown HSPA9 substrate and cell survival/death effector
  • HSPA9 facilitates BRAF-mutant tumor cell survival by suppressing SLC25A6-mediated mitochondrial membrane permeability
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    decreased cellular ATP levels, limited cell growth and induced a stress-like response
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS