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FLASH GENE
Symbol SLC25A25 contributors: - updated : 21-04-2005
HGNC name solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
HGNC id 20663
Location 9q34.11      Physical location : 130.830.478 - 130.871.523
Synonym name
  • mitochondrial Ca2+-dependent solute carrier
  • short calcium-binding mitochondrial carrier 2
  • mitochondrial ATP-Mg/Pi carrier (Small calcium-binding mitochondrial carrier 2)
  • Synonym symbol(s) MCSC, PCSCL, SCAMC-2, KIAA1896
    DNA
    TYPE functioning gene
    STRUCTURE 10.00 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 3240 52 469 - Del Arco (04)
    lacks the first EF-hand motif
    - splicing 3433 - 503 restricted to lung and kidney Del Arco (04)
    4 EF-hand motifs
    - splicing 3293 54 489 restricted to brain Del Arco (04)
    lacks the first EF-hand
    - splicing 3264 - 366 - Del Arco (04)
    lacks the first 3 EF-hand motifs
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   predominantly
    Nervousbrainlimbic systemhippocampus highly
     brainbasal nucleicaudate nucleus highly
    Reproductivefemale systemovary  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines liver carcinoma
    fluid/secretion
    at STAGE
    physiological period fetal
    Text liver, highly
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two EF-hand calcium binding motifs
  • six transmembrane regions
  • HOMOLOGY
    interspecies homolog to rattus Pcscl
    homolog to murine Slc25a25
    intraspecies homolog to SLC25A24
    homolog to SLC25A23
    Homologene
    FAMILY mitochondrial solute carrier family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    basic FUNCTION
  • may play an important role in regulating the function of hepatocytes rather than in differentiation
  • responsible for the uptake or efflux of adenine nucleotides into or from mitochondria and hence for the variation in the matrix adenine nucleotide content (which changes in physiopathological situations)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS mitochondrial transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • Ca2+ binding
  • ATP-Mg binding
  • phosphate binding
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS