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FLASH GENE
Symbol SLC25A22 contributors: mct/npt - updated : 18-12-2009
HGNC name solute carrier family 25 (mitochondrial carrier: glutamate), member 22
HGNC id 19954
Corresponding disease
EIEE3 epileptic encephalopathy, early infantile, 3
Location 11p15.5      Physical location : 790.475 - 798.269
Synonym name
  • mitochondrial glutamate carrier 1
  • glutamate/H(+) symporter 1
  • Synonym symbol(s) GC1, FLJ13044, NET44
    DNA
    TYPE functioning gene
    STRUCTURE 5.75 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    PTDSS2 11p15 phosphatidylserine synthase 2 RNH 11p15.5 ribonuclease/angiogenin inhibitor LOC387735 11 similar to Collagen alpha 1(V) chain precursor HRAS 11p15.5 v-Ha-ras Harvey rat sarcoma viral oncogene homolog DKFZp761L1518 11p15.5 hypothetical protein DKFZp761L1518 MGC35138 11p15.5 hypothetical protein MGC35138 C11orf13 11p15,5 chromosome 11 open reading frame 13 KIAA1542 11p15.5 CTD-binding SR-like protein rA9 IRF7 11p15,5 interferon regulatory factor 7 MUCDHL 11p15,5 mucin and cadherin-like SCT 11p15.5 secretin DRD4 11p15.5 dopamine receptor D4 LOC387736 11 LOC387736 DEAF1 11p15,5 deformed epidermal autoregulatory factor 1 (Drosophila) LOC283232 11p15.5 hypothetical protein LOC283232 EPS8L2 11p15.5 EPS8-like 2 TALDO1 11p15.5-p15.4 transaldolase 1 FLJ34283 11p15.5 hypothetical protein FLJ34283 NS3BP 11p15.5 NS3BP BM88 11p15.5 NS3BP SLC25A22 11p15.5 solute carrier family 25 (mitochondrial carrier: glutamate), member 22 LOC387737 11 LOC387737 LRDD 11pter-p15.5 leucine-rich and death domain containing RPLP2 5q31 ribosomal protein, large P2 TTS-2.2 11p15.5 transport-secretion protein 2.2 MGC45840 11p15.5 hypothetical protein MGC45840 CD151 11p15.5 CD151 antigen POLR2L 11p15 polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa TM4SF7 11p15.5 transmembrane 4 superfamily member 7 MGC3234 11p15.5 hypothetical protein MGC3234 AP2A2 11p15.5 adaptor-related protein complex 2, alpha 2 subunit
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2780 - 323 - Molinari (2005)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Endocrinepancreas   highly
    Nervousbrainforebrain   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...)
    Nervousastrocyte
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four EF-hand calcium-binding domains
  • three solcar repeats
  • HOMOLOGY
    interspecies ortholog to murine Slc25a22
    Homologene
    FAMILY
  • mitochondrial carrier family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • involved in the transport of glutamate across the inner mitochondrial membrane, glutamate is cotransported with H(+)
  • may be having a function in the urea cycle
  • catalyze the transport of glutamate across the inner mitochondrial membrane, either by proton co-transport or in exchange for hydroxyl ions (Casimir 2009)
  • having a role in control of insulin secretion upon elevated glucose stimulation (Casimir 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text L-glutamate
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Slc25a22
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION calcium-dependent mitochondrial aspartate and glutamate carrier. may be having a function in the urea cycle.
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EIEE3
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS