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FLASH GENE
Symbol SLC25A17 contributors: mct - updated : 31-01-2018
HGNC name solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17
HGNC id 10987
Location 22q13.1      Physical location : 41.165.640 - 41.215.392
Synonym name
  • peroxisomal membrane protein PMP34
  • Synonym symbol(s) PMP34
    DNA
    TYPE functioning gene
    STRUCTURE 48.27 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D22S283 - SLC25A17 - XRCC6 - ADSL - ACO2 - D22S272 - qter
    Authors Gene Map (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2347 - 270 - 2012 22185573
    - - 2075 - 234 - 2012 22185573
    - - 2294 34.6 307 - 2012 22185573
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Endocrineadrenal gland    
     pancreas    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six membrane-spanning regions
  • three tandemly repeated mitochondrial carrier protein domains
  • three SOLCAR repeats
  • secondary structure
  • tripartite structure, six transmembrane alpha-helices and a 3-fold repeated signature motifs
  • HOMOLOGY
    interspecies homolog to murine Slc25a17
    homolog to Drosophila CG1326
    Homologene
    FAMILY solute carrier protein family 25, mitochondrial
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,peroxisome
    text colocalizes with the dimeric peroxisomal thiolase
    basic FUNCTION
  • having a role in transport of adenine nucleotide across the peroxisomal membrane
  • only member of the mitochondrial carrier family that has previously been shown to be localized in the peroxisomal membrane
  • its main function is probably to transport free CoA, FAD and NAD+ into peroxisomes in exchange for intraperoxisomally generated PAP, FMN and AMP
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text energy transfer
    PATHWAY
    metabolism energetic
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a transporter of CoA, FAD, FMN and AMP, and to a lesser extent of NAD+, PAP (adenosine 3',5'-diphosphate) and ADP
  • PEX16 mediates the peroxisomal trafficking of two distinct peroxisomal membrane proteins, PEX3 and SLC25A17, via the ER
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS