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FLASH GENE
Symbol SLC25A16 contributors: - updated : 18-03-2006
HGNC name solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16
HGNC id 10986
Location 10q21.3-q22.1      Physical location : 70.242.097 - 70.287.584
Synonym symbol(s) D10S105E, HGT, GDA, GDC, ML7
DNA
TYPE functioning gene
STRUCTURE 46.00 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
LOC340888 10q22.1 similar to aldo-keto reductase family 1, member B10; aldose reductase-like 1; aldo-keto reductase family 1, member B11 (aldose reductase-like); aldose reductase-like peptide; aldose reductase-related protein; small intestine reducta JDP1 10q21.1 similar to aldo-keto reductase family 1, member B10; aldose reductase-like 1; aldo-keto reductase family 1, member B11 (aldose reductase-like); aldose reductase-like peptide; aldose reductase-related protein; small intestine reducta LOC389974 10 similar to 60S ribosomal protein L12 SIRT1 10q21.3 sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) DKFZP564G092 10q22.1 DKFZP564G092 protein MYOP ATOH7 10q22.2 atonal homolog 7 (Drosophila) LOC389975 10 similar to keratin 19; keratin, type I cytoskeletal 19; keratin, type I, 40-kd; cytokeratin 19; 40-kDa keratin intermediate filament precursor gene MAWBP 10q21.1 similar to keratin 19; keratin, type I cytoskeletal 19; keratin, type I, 40-kd; cytokeratin 19; 40-kDa keratin intermediate filament precursor gene HNRPH3 10q22 heterogeneous nuclear ribonucleoprotein H3 (2H9) RUFY2 10q22.2 RUN and FYVE domain containing 2 DNA2L 10q21.3-q22.1 DNA2 DNA replication helicase 2-like (yeast) SLC25A16 10q21.3-q22.1 solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16 LCX 10q21 leukemia-associated protein with a CXXC domain CARP-1 10q22.1 cell-cycle and apoptosis regulatory protein 1 C10orf24 10q22.1 chromosome 10 open reading frame 24 DDX50 10q22.1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 DDX21 10q21 DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 KIAA1279 10q22.1 KIAA1279 LOC389976 10 similar to actin 3 - fruit fly (Drosophila melanogaster) (fragments) PRG1 10q22.1 proteoglycan 1, secretory granule VPS26 10q21.1 vacuolar protein sorting 26 (yeast) SUPV3L1 10q22.1 suppressor of var1, 3-like 1 (S. cerevisiae) FLJ22761 10q22.1 hypothetical protein FLJ22761 HK1 10q22 hexokinase 1
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland   highly
 pancreas    
Nervousbrain    
Reproductivemale systemprostate   
Respiratoryrespiratory tractlarynx  highly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
three tandemly repeated mitochondrial carrier protein domains
HOMOLOGY
interspecies homolog to Drosophila CG1628
homolog to C.elegans T10F2.2
intraspecies homolog to adenine nucleotide translocator
Homologene
FAMILY solute carrier family 25,mitochondrial
CATEGORY antigen , transport carrier
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,inner
basic FUNCTION
  • facilitating the rapid transport and exchange of molecules betwenn the cytosol and the mitochondrial matrix space
  • required for the accumulation of coenzyme A in the mitochondrial matrix
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport , mitochondrial transport
    text energy transfer
    PATHWAY
    metabolism energetic
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility Graves disease (possible role)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS