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FLASH GENE
Symbol SLC25A11 contributors: - updated : 22-12-2007
HGNC name solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
HGNC id 10981
Location 17p13.3      Physical location : 4.840.427 - 4.843.462
Synonym symbol(s) SLC20A4,OGC
DNA
TYPE functioning gene
STRUCTURE 2.00 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
twelve putative transmembrane segments (12 TM),cytoplasmic N and C termini with a sulfate transporter family motif and an STAS domain (sulfate transporter and anti sigma antagonist)
HOMOLOGY
interspecies homolog to murine Slc25a11
Homologene
FAMILY mitochondrial carrier family
CATEGORY transport carrier
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,inner
basic FUNCTION
  • oxoglutarate-isocitrate shuttle,gluco neogenesis andnitrogen metabolism
  • catalyzing the transport of 2-oxoglutarate for malate and other dicarboxylic acids
  • involved in malate-aspartate shuttle
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport , mitochondrial transport
    text
  • small molecule transport
  • energy transfer
  • PATHWAY
    metabolism energetic
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS