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FLASH GENE
Symbol SLC25A10 contributors: - updated : 16-06-2007
HGNC name solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
HGNC id 10980
Location 17q25.3      Physical location : 79.679.370 - 79.688.041
Synonym name dicarboxylate ion carrier
Synonym symbol(s) DIC
DNA
TYPE functioning gene
STRUCTURE 8.00 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
motif repetitive sequence   ALU
text structure
  • five short interspersed repetitive ALU sequence in the first intron
    • MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinelarge intestinecolon highly
     intestinesmall intestine  highly
    Nervousbrain    
    Reproductivefemale systemovary  highly
    Urinarykidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three tandemly repeated mitochondrial carrier protein domains
    • HOMOLOGY
    interspecies homolog to rattus mitochondrial dicarboxylate carrier
    Homologene
    FAMILY mitochondrial carrier family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    basic FUNCTION
  • involved in gluconeogenesis and ureogenesis
  • involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite
    • or thiosulfate across mitochondrial inner membrane
  • plays an important role in supplying malate for citrate transport required for fatty acid synthesis and inhibition of SLC25A10 might effectively reduce lipid accumulation in adipose tissues
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text
  • small molecule transport
  • energy transfer
    • PATHWAY
    metabolism energetic
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS