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FLASH GENE
Symbol SLC24A3 contributors: mct - updated : 10-09-2009
HGNC name solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
HGNC id 10977
Location 20p11.23      Physical location : 19.193.289 - 19.703.540
Synonym name
  • Na(+)/K(+)/Ca(2+)-exchange protein 3
  • sodium calcium exchanger
  • Synonym symbol(s) NCKX3
    DNA
    TYPE functioning gene
    STRUCTURE 510.25 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    SNX5 20pter-q11.23 sorting nexin 5 C20orf72 20p11.23 chromosome 20 open reading frame 72 PTMAP3 20p11.23 prothymosin, alpha pseudogene 3 (gene sequence 34) ZNF339 20pter-q11.23 zinc finger protein 339 RPL15P1 20p11.23 ribosomal protein L15 pseudogene 1 CSRP2BP 20p11.23 CSRP2 binding protein ZNF133 20p11.23-p11.22 zinc finger protein 133 (clone pHZ-13) C20orf12 20p11.23 chromosome 20 open reading frame 12 POLR3F 20p11.23 polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa RBBP9 20p11.2 retinoblastoma binding protein 9 RPS19P1 20p11.23 ribosomal protein S19 pseudogene 1 SEC23B 20pter-p12.3 Sec23 homolog B (S. cerevisiae) LOC388789 20 hypothetical gene supported by AF147354 HARS2 20p11.23 histidyl-tRNA synthetase 2 HSPC072 20p11.23 HSPC072 protein C20orf78 20p11.23 chromosome 20 open reading frame 78 C20orf79 20 chromosome 20 open reading frame 79 SLC24A3 20p13 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 LOC388790 20 LOC388790 RPL12L3 20p11.22 ribosomal protein L12-like 3 RIN2 20p11.22 Ras and Rab interactor 2 NAT5 20p11.22 N-acetyltransferase 5 (ARD1 homolog, S. cerevisiae) CRNKL1 20q12 Crn, crooked neck-like 1 (Drosophila) C20orf26 20p11.23 chromosome 20 open reading frame 26 RPL17P1 20p11.2 ribosomal protein L17 pseudogene 1 INSM1 20p11.21 insulinoma-associated 1 KIAA1272 20p11.22 KIAA1272 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 3905 - 644 - 2001 11294880
    EXPRESSION
    Rna function highly in brain, smooth muscle, uterus, aorta, intestine
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvesselsaorta   
    Nervousbraindiencephalonthalamusnucleihighly
     braindiencephalonhypothalamus highly
    Reproductivemale systemprostate  moderately
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularsmoothvessel highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two large hydrophilic loops
  • two sets of transmembrane spanning segments (TMs)
  • the first large hydrophilic loop is located extracellularly at the N-terminus
  • the other is cytoplasmic and separates the two sets of TMs
  • HOMOLOGY
    intraspecies homolog to NCKX1
    homolog to NCKX2
    Homologene
    FAMILY
  • sodium/potassium/calcium exchanger family
  • SLC24A subfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • K dependent (Na+) (Ca2+) exchanger regulating intracellular Ca2+ concentration
  • polytopic membrane protein that plays a critical role in Ca(2+) homeostasis in retinal rod and cone photoreceptors
  • playing a role in mediating agonist-stimulated [Ca2+]cyt and thereby vascular tone
  • probably play a particularly prominent role in regulating Ca2+ flux in environments which experience wide and frequent fluctuations in Na+ concentration
  • plays a critical role in the transport of an intracellular calcium and potassium ion in exchange for four extracellular sodium ions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS