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FLASH GENE

Symbol

SLC24A3

contributors: mct - updated : 10-09-2009

HGNC name	solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
HGNC id	10977

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	20p11.23      Physical location : 19.193.289 - 19.703.540
Synonym name	Na(+)/K(+)/Ca(2+)-exchange protein 3
	sodium calcium exchanger
Synonym symbol(s)	NCKX3

DNA

TYPE	functioning gene
STRUCTURE	510.25 kb     17 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_020689 17 - 3905 NP_065740 - 644 - 2001 11294880

EXPRESSION

Rna function	highly in brain, smooth muscle, uterus, aorta, intestine
Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessels aorta       Nervous brain diencephalon thalamus nuclei highly   brain diencephalon hypothalamus   highly Reproductive male system prostate     moderately Urinary kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular smooth vessel   highly

cells

System Cell Pubmed Species Stage Rna symbol Cardiovascular endothelial cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two large hydrophilic loops
	two sets of transmembrane spanning segments (TMs)
	the first large hydrophilic loop is located extracellularly at the N-terminus
	the other is cytoplasmic and separates the two sets of TMs

HOMOLOGY

intraspecies	homolog to NCKX1
	homolog to NCKX2

Homologene

FAMILY	sodium/potassium/calcium exchanger family
	SLC24A subfamily

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	K dependent (Na+) (Ca2+) exchanger regulating intracellular Ca2+ concentration
	polytopic membrane protein that plays a critical role in Ca(2+) homeostasis in retinal rod and cone photoreceptors
	playing a role in mediating agonist-stimulated [Ca2+]cyt and thereby vascular tone
	probably play a particularly prominent role in regulating Ca2+ flux in environments which experience wide and frequent fluctuations in Na+ concentration
	plays a critical role in the transport of an intracellular calcium and potassium ion in exchange for four extracellular sodium ions

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS