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FLASH GENE
Symbol SLC24A2 contributors: mct/npt - updated : 10-09-2009
HGNC name solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
HGNC id 10976
Location 9p22.1      Physical location : 19.507.450 - 19.788.591
Synonym name
  • Na(+)/K(+)/Ca(2+)-exchange protein 2
  • retinal cone Na-Ca+K exchanger
  • Synonym symbol(s) NCKX2
    DNA
    TYPE functioning gene
    STRUCTURE 270.95 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    ADAMTSL1 9p22.1-p21.3 ADAMTS-like 1 FLJ35283 9p22.1 hypothetical protein FLJ35283 MGC35182 9p22.1 hypothetical protein MGC35182 PSMC3P 9p proteasome (prosome, macropain) 26S subunit, ATPase, 3 pseudogene RRAGA 9p21.3 Ras-related GTP binding A FAM29A 9p22.1 family with sequence similarity 29, member A ADFP 9p23-p22 adipose differentiation-related protein LOC253482 9p21.3 similar to 40S ribosomal protein S6 (Phosphoprotein NP33) C9orf55 9p21.3 chromosome 9 open reading frame 55 RPS6 9p22 ribosomal protein S6 LOC340485 9p21.3 similar to cancer related gene-liver 1 LOC392288 9 similar to microtubule-associated proteins 1A/1B light chain 3 SLC24A2 9p22-p13 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 LOC389706 9 LOC389706 SMNP 9 LOC389706 MLLT3 9p22 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 KIAA1797 9p21 KIAA1797 IFNB1 9p22 interferon, beta 1, fibroblast IFNW1 9p22 interferon, omega 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2221 - 661 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   lowly
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularsmoothvessel  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell
    Visualcone photoreceptor
    Visualganglion cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two sets of hydrophobic transmembrane segments each with a alpha repeat through to form the ion binding pocket for transport, separated by a large cytosolic loop
  • twelve transmembrane segments
  • conjugated GlycoP
    isoforms Precursor 58 aa signal peptide
    HOMOLOGY
    interspecies homolog to rattus Slc24a2 (89.7 pc)
    homolog to murine Slc24a2 (90.2 pc)
    intraspecies homolog to SLC24A1
    Homologene
    FAMILY
  • sodium/potassium/calcium exchanger family
  • SLC24A subfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • acting as a critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness
  • playing a key role in the process of light adaptation
  • polytopic membrane protein that plays a critical role in Ca(2+) homeostasis in retinal rod and cone photoreceptors (Kinjo 2003)
  • playing a role in mediating agonist-stimulated [Ca2+]cyt and thereby vascular tone (Dong 2006)
  • probably play a particularly prominent role in regulating Ca2+ flux in environments which experience wide and frequent fluctuations in Na+ concentration (Lytton 2007)
  • bidirectional transporters normally extruding Ca(2+) from the cell (forward exchange), but also able to carry Ca(2+) into the cell (reverse exchange) when the transmembrane Na(+) gradient is reversed (Schnetkamp 2004)
  • implicated in a regulatory kinetic state of Ca2+ transport that may play a prominent role in regulation of Ca2+ extrusion in cellular environments such as neuronal synapses that experience frequent and dynamic Ca2+ fluxes (Altimimi 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text transports (antiport) a Ca(2+) and a K(+) in exchange for four Na(+)
    PATHWAY
    metabolism
    signaling sensory transduction/vision
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • K+
  • Na+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS