Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SLC22A9 contributors: mct - updated : 07-01-2021
HGNC name solute carrier family 22 (organic anion/cation transporter), member 9
HGNC id 16261
Location 11q12.3      Physical location : 63.137.260 - 63.177.710
Synonym name
  • organic anion transporter 7
  • Synonym symbol(s) OAT4, FLJ23666, HOAT4, OAT7, UST3H, ust3
    DNA
    TYPE functioning gene
    STRUCTURE 40.47 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    text structure
  • one HNF-1A binding elements in the proximal promoter (
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2327 - 553 - 2001 11327718
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • twelve transmembrane domains (12TM), with cytoplasmic N and C termini
  • one nucleotide (ATP/GTP) binding site motif
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • uptake of fetal derived steroid sulfatin by trophoblast
  • mediated Na(+)-independent, high-affinity transport of sulfate-conjugated steroids, estrone sulfate, and dehydroepiandrosterone sulfate
  • involved in the transport of anionic substances such as sulfate-conjugates in exchange for butyrate in hepatocytes
  • with SLC22A12, are key transporters in renal reabsorption of perfluorocarboxylates
  • marked interindividual variability likely in the hepatic expression of SLC22A7/SLC22A9, which may contribute to the pharmacokinetic variability of their substrates
  • OATS4 (SLC22A9, SLC22A10, SLC2A24, and SLC22A25) members are specifically associated with conjugated sex hormones
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • transactivated by hepatocyte nuclear factor-1 (HNF-1A)
  • HNF4A is a major transcriptional regulator of SLC22A9 (
  • pravastatin is the first identified SLC22A9 drug substrate
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS