Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SLC22A8 contributors: mct - updated : 07-10-2015
HGNC name solute carrier family 22 (organic anion transporter), member 8
HGNC id 10972
Location 11q12.3      Physical location : 62.760.296 - 62.783.317
Synonym name organic anion transporter, member 3
Synonym symbol(s) OATP3, OAT3, MGC24086, ROCT
DNA
TYPE functioning gene
STRUCTURE 23.02 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 2207 59.8 542 - Windass (2007)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   lowly
Urinarykidneytubule  moderately Homo sapiens
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialabsorptive excretoryrenal tubular epithelium   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Urinaryepithelial cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ten (? twelve) transmembrane segments protein
  • a large acidic cytoplasmic C terminal domain
  • HOMOLOGY
    Homologene
    FAMILY
  • major facilitator superfamily
  • organic cation transporter family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text basolateral membrane
    basic FUNCTION
  • mediating the coupled exchange of alpha-ketoglutarate with multiple organic ions
  • polyspecific transporter for organic cations
  • mediating the initial steps in the transport of organic anionic drugs between the blood and proximal tubule cells of the kidney
  • play crucial roles in the renal secretion of various drugs (Ogasawara 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other SLC22A1, SLC22A6, SLC22A8 regulation during development and maturation of the kidney proximal tubule
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS