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FLASH GENE
Symbol SLC22A7 contributors: mct/pgu - updated : 04-04-2012
HGNC name solute carrier family 22 (organic anion transporter), member 7
HGNC id 10971
Location 6p21.1      Physical location : 43.265.997 - 43.273.275
Synonym name
  • organic anion transporter 2
  • liver-specific transporter
  • novel liver transporter
  • Synonym symbol(s) OAT2, NLT, MGC45202, MGC24091
    DNA
    TYPE functioning gene
    STRUCTURE 7.28 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter - D6S273 - SLC22A7 - D6S271 - D6S459 - D6S452 - D6S436 - D6S466 - cen
    Physical map
    RPL7L1 6p21.1 ribosomal protein L7-like 1 PTCRA 6p21.2-p21.3 pre T-cell antigen receptor alpha TNRC5 6pter-p12.1 trinucleotide repeat containing 5 LOC389390 6 LOC389390 RPL24P4 6p21.1 ribosomal protein L24 pseudogene 4 GNMT 6p12 glycine N-methyltransferase PEX6 6p21.1 peroxisomal biogenesis factor 6 PPP2R5D 6p21.1 protein phosphatase 2, regulatory subunit B (B56), delta isoform MEA 6p21.3-p21.1 male-enhanced antigen KLHDC3 6p21.1 kelch domain containing 3 C6orf153 6p21.1 chromosome 6 open reading frame 153 KIAA0076 6p21.1 chromosome 6 open reading frame 153 MRPL2 6p21.3 mitochondrial ribosomal protein L2 KNSL8 6p21.1 kinesin-like 8 PTK7 6p21.1-p12.2 PTK7 protein tyrosine kinase 7 SRF 6p12.3 serum response factor (c-fos serum response element-binding transcription factor) PARC 6p21.1 p53-associated parkin-like cytoplasmic protein C6orf108 6p21.1 chromosome 6 open reading frame 108 TTBK1 6p21.1 tau tubulin kinase 1 SLC22A7 6p21.2-p21.1 solute carrier family 22 (organic anion transporter), member 7 LOC389391 6 similar to thymus LIM protein TLP-B ZNF318 6pter-p12.1 zinc finger protein 318 ABCC10 6p21.2-p21.1 ATP-binding cassette, sub-family C (CFTR/MRP), member 10 EGFL9 6p21.1 EGF-like-domain, multiple 9 TJP4 6p12.3 tight junction protein 4 (peripheral) C6orf154 6p21.1 chromosome 6 open reading frame 154 C6orf109 6p21.1 chromosome 6 open reading frame 109 POLR1C 6p21.1 polymerase(RNA)1 polypeptide C, 30kDa XPO5 6p21.1 exportin 5 POLH 6p21.1-p12 polymerase (DNA directed), eta GTPBP2 6p21-p12 GTP binding protein 2 MAD2L1BP 6p21.1 MAD2L1 binding protein C6orf206 6p21.1 chromosome 6 open reading frame 205 MRPS18A 6p21.3 mitochondrial ribosomal protein S18A
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2559 - 548 - 2008 18216183
    10 - 2553 - 546 - 2008 18216183
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver     Homo sapiens
    Urinarykidneytubule   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestivehepatocyte Homo sapiens
    Urinaryepithelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • twelve transmembrane domains (12TM)
  • cytoplasmic N and C termini
  • one nucleotide (ATP/GTP) binding site motif
  • HOMOLOGY
    Homologene
    FAMILY
  • major facilitator superfamily
  • organic cation transporter family
  • SLC22 family of transport proteins
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text basolateral membrane
    basic FUNCTION
  • liver specific transport protein
  • play crucial roles in the renal secretion of various drugs
  • facilitative transporter for cGMP and other guanine nucleotides
  • may be involved in the regulation of cellular metabolism through the transport of short chain fatty acid propionate in the kidneys and the liver
  • operates as glutamate efflux transporter, and catalyses uptake of orotic acid
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS