Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

SLC22A18AS

contributors: mct/npt - updated : 09-01-2009

HGNC name	solute carrier family 22 (organic cation transporter), member 18 antisense
HGNC id	10965

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11p15.5      Physical location : 2.909.327 - 2.925.175
Synonym name	Beckwith-Wiedemann region 1B
	Beckwith-Wiedemann syndrome chromosome region 1, candidate b
	organic cation transporter-like 2 antisense
	solute carrier family 22 (organic cation transporter), member 1-like antisense
Synonym symbol(s)	BWR1B, BWSCR1B, ORCTL2S, SLC22A1LS, p27-BWR1B

DNA

TYPE	functioning gene
STRUCTURE	12.76 kb     4 Exon(s)

regulatory sequence	Promoter (CAAT box) (TATA box)
	Binding site   hormone
text structure	dual promoters (P1 and P2) and both are devoid of consensus TATA and CCAAT boxes
	expression of this gene was found to be methylation-dependent and histone acetylation-independent
	P1 promoter harbors a putative Sp1 binding site, and Sp1 is the transactivator of the P1 promoter

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 4 - 1565 - 253 - Bajaj (2008)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive intestine large intestine colon       liver       predominantly Reproductive female system placenta         male system prostate       Urinary kidney       predominantly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	liver, kidney predominantly

IMPRINTING	paternally
text	imprinting of the paternal allele in five fetal tissues: brain, liver, placenta, kidneys and lungs
	biallelic expression in adult breast tissue

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	twelve transmembrane segments protein
	a large acidic cytoplasmic C terminal domain

HOMOLOGY

Homologene

FAMILY

solute carrier family 22, organic cation

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus
text	translated into a novel protein of 30 kDa with a cytoplasmic localization

basic FUNCTION

unknown

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS