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FLASH GENE
Symbol SLC22A13 contributors: mct/npt - updated : 30-09-2009
HGNC name solute carrier family 22 (organic anion transporter), member 13
HGNC id 8494
Location 3p22.2      Physical location : 38.307.297 - 38.319.806
Synonym name organic cationic transporter-like 3
Synonym symbol(s) OCTL1, OCTL3, ORCTL3, OAT10, ORCTL-3
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem, component of a cluster
text tandemly oriented with SLC22A14 and clustered within a 52-kb region of genomic DNA.
STRUCTURE 12.48 kb     10 Exon(s)
MAPPING cloned Y linked   status confirmed
Map pter - TGP230L - ITGA9 - CTDSPL - VILL - ACAA1 - MYD88 - OSR1 - PLCD1 - SLC22A13 - SLC22A14 - XYLB - ACVR2B - ENDOGL1 /ENDOGL2 - cen
Authors Nishiwaki (98), Daigo (99)
Physical map
LRRFIP2 3p24.3-p23 leucine rich repeat (in FLII) interacting protein 2 FLJ31715 3p22.1 hypothetical protein FLJ31715 GOLGA4 3p22-p21.3 golgi autoantigen, golgin subfamily a, 4 APRG1 3p22.1 AP20 region protein ITGA9 3p21.3 integrin, alpha 9 CTDSPL 3p21.3 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like VILL 3p21.3 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like PLCD1 3p21.3 phospholipase C, delta 1 DLEC1 ACAA1 3p23-p22 acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3-oxoacyl-Coenzyme A thiolase) MYD88 3p22-p21.3 myeloid differentiation primary response gene (88) OSR1 3p22-p21.3 oxidative-stress responsive 1 SLC22A13 3p22-p21.3 solute carrier family 22 (organic cation transporter), member 13 SLC22A14 3p22-p21.3 solute carrier family 22 (organic cation transporter), member 14 XYLB 3p22-p21.3 xylulokinase homolog (H. influenzae) ACVR2B 3p22 activin A receptor, type IIB ENDOGL1 3p21.3 endonuclease G-like 1 LOC391528 3 similar to ribosomal protein L18a; 60S ribosomal protein L18a SCN5A 3p21 sodium channel, voltage-gated, type V, alpha (long QT syndrome 3) SCN10A 3p21-p22 sodium channel, voltage-gated, type X, alpha SCN11A 3p24-p21 sodium channel, voltage-gated, type XI, alpha KIAA1449 3p21.33 WD repeat endosomal protein GORASP1 3p22-p21.33 golgi reassembly stacking protein 1, 65kDa STI2 3p21.33 TPR domain containing STI2 AXUD1 3p22 AXIN1 up-regulated 1 CMYA1 3p21.33 cardiomyopathy associated 1 CX3CR1 3p21.32-p21.31 chemokine (C-X3-C motif) receptor 1 CCR8 3p21.32-p21.31 chemokine (C-C motif) receptor 8 hnRNPA1p 3p21.33 heterogeneous nuclear ribonucleoprotein A1 pseudogene
regionally located tightly linked with ORCTL3 in head to head orientation
RNA
TRANSCRIPTS type messenger
text alternatively spliced transcripts (Nishiwaki)
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 2555 60.7 551 - Irshad (2009)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestiveintestine   moderately
Nervousbrain   moderately
Urinarykidney   specific
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ten putative transmembrane domains
  • three A-C motifs specific for family I transporters
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus Slc22a13 (72.8 pc)
    homolog to murine Slc22a13 (73 pc)
    Homologene
    FAMILY
  • major facilitator superfamily
  • organic cation transporter family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text multi-pass membrane protein
    basic FUNCTION
  • acting as a polyspecific organic cation transporter
  • may be the molecular equivalent of the postulated high affinity nicotinate transporter in kidneys and intestine (Bahn 2008)
  • may represent a low affinity urate transporter (Bahn 2008)
  • induces apoptosis independently of its putative transporter activity and brings about apoptosis by an endoplasmic reticulum stress-mediated mechanism (Irshad 2009)
  • inducing the signal for apoptosis at the ER, an organelle with a well-recognized function in apoptosis (Irshad 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text organic cation transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in human kidney tumors (Irshad 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS