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FLASH GENE
Symbol SLC22A11 contributors: mct/npt - updated : 13-04-2010
HGNC name solute carrier family 22 (organic anion/cation transporter), member 11
HGNC id 18120
Location 11q13.1      Physical location : 64.323.097 - 64.338.998
Synonym name solute carrier family 22 member 11
Synonym symbol(s) OAT4, MGC34282
DNA
TYPE functioning gene
STRUCTURE 15.90 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 2545 - 550 - Kimura 2002)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Urinarykidneytubuleconvoluted tubuleproximal tubule 
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twelve transmembrane domains (12TM)
  • cytoplasmic N and C termini
  • one nucleotide (ATP/GTP) binding site motif
  • HOMOLOGY
    Homologene
    FAMILY
  • major facilitator superfamily
  • organic cation transporter family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text located at the apical membrane of proximal tubule cells (Hagos 2007)
    basic FUNCTION
  • mediating organic transport
  • transport of various cephalosporines, tetracyclines, prostaglandins
  • involved in renal secretion and reabsorption of endogenous substances as well as many drugs and xenobiotics (Hagos 2007)
  • play crucial roles in the renal secretion of various drugs (Ogasawara 2008)
  • long-postulated, low-affinity apical urate anion exchanger that facilitates hydrochlorothiazide-associated hyperuricemia (Hagos 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction of PDZ proteins with SLC22A11, that may be cell-specific (in placenta, a different set of interacting proteins from PDZK1 and SLC9A3R1 may be required to modulate its activity) (Zhou 2008)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene could be used as markers for certain diseases including osteoporosis (Lee 2008)
    Marker
    Therapy target
    ANIMAL & CELL MODELS