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FLASH GENE
Symbol SLC20A1 contributors: mct/pgu - updated : 27-04-2011
HGNC name solute carrier family 20 (phosphate transporter), member 1
HGNC id 10946
Location 2q13      Physical location : 113.403.526 - 113.421.398
Synonym name
  • gibbon ape leukemia virus receptor 1
  • leukemia virus receptor 1 homolog
  • sodium-dependent phosphate transporter 1
  • Synonym symbol(s) GLVR1, FLJ41426, Glvr-1, PIT1, PiT-1, DKFZp686J2397
    DNA
    TYPE functioning gene
    STRUCTURE 17.88 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map cen - D2S2016 - D2S340 - D2S1893 - D2S2087 - D2S1888 - D2S1896 - SLC20A1 - IL1A - IL1B - IL1RN - D2S43 /PAX8 PAX8 - D2S178 - D2S121 - D2S308 - qter
    Authors SCW2-4 (96)
    Physical map
    ANAPC1 2q12.1 anaphase-promoting complex 1 (meiotic checkpoint regulator) MERTK 2q14.1 c-mer proto-oncogene tyrosine kinase FLJ14681 2q13 hypothetical protein FLJ14681 FLJ37440 2q13 hypothetical protein FLJ37440 LOC84524 2q13 zinc finger protein FLJ41410 2q13 FLJ41410 protein LOC389020 2 similar to RAN-binding protein 2-like 1 isoform 1; sperm membrane protein BS-63; RAN-binding protein 2-like 1 TTL 2q13 similar to RAN-binding protein 2-like 1 isoform 1; sperm membrane protein BS-63; RAN-binding protein 2-like 1 POLR1B 2q13 polymerase (RNA)1polypeptide B, 128kDa C2orf9 2q13 chromosome 2 open reading frame 9 SLC20A1 2q11-q14 solute carrier family 20 (phosphate transporter), member 1 FLJ40629 2q14.1 hypothetical protein FLJ40629 IL1A 2q13 interleukin 1, alpha IL1B 2q13 interleukin 1, beta IL1F7 2q12.1-q14.1 interleukin 1 family, member 7 (zeta) IL1F9 2q13 interleukin 1 family, member 9 IL1F6 2q12-q14.1 interleukin 1 family, member 6 (epsilon) IL1F8 2q12-q14.1 interleukin 1 family, member 8 (eta) IL1F5 2q12.1 interleukin 1 family, member 5 (delta) IL1F10 2q12 interleukin 1 family, member 10 (theta) IL1RN 2q13-q14.2 interleukin 1 receptor antagonist TIC 2q13 interleukin 1 receptor antagonist PAX8 2q12-q14 paired box gene 8 LOC391427 2 similar to Ig kappa chain precursor V region (orphon V108) - human  (fragment) CBWD2 2q13 COBW domain containing 2 FOXD4L1 2q13 COBW domain containing 2 LOC284964 2q14.1 similar to bA395L14.5 (novel phosphoglucomutase like protein) LOC389021 2 hypothetical gene supported by BC063555 MGC13005 2q14.1 hypothetical protein MGC13005 RPL23AP7 2q14 ribosomal protein L23a pseudogene 7 RABL2A 2q13 RAB, member of RAS oncogene family-like 2A bA395L14.12 2q14.1 u2 small nuclear ribonucleoprotein polypeptide A' pseudogene bA395L14.13 2q14.1 acrosin-like protease
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 3297 - 679 - 2007 17494632
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivesalivary gland   highly
    Endocrinethyroid   highly
    Nervousbrain    
    Reproductivefemale systemuterus  highly
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Connectivebone   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    multiple potential transmembrane domains
    HOMOLOGY
    interspecies homolog to murine Slc20a1
    homolog to Drosophila CG7628
    homolog to C.elegans C48A7.2
    Homologene
    FAMILY
    CATEGORY receptor membrane , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • putatively involved in the regulation of Pi handling in bone forming cells
  • sodium-dependent phosphate symporter
  • critical gene for normal developmental liver growth (
  • involved in phosphate uptake (essential role for smooth muscle cells calcification and phenotypic modulation in response to elevated phosphate)
  • is involved in cell proliferation, tumor growth and cell signaling independently of its transport function
  • functions as a sodium-Pi (inorganic phosphate) symporter
  • could play a role during cancer pathogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text small molecule transport
    PATHWAY
    metabolism other
    signaling
    phosphate
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PDGFRB is involved in angiogenesis and in the regulation of inorganic phosphate (Pi) transport in vascular smooth muscle cells via SLC20A1
  • NELL1 increases pre-osteoblast mineralization using both phosphate transporter SLC20A1, SLC20A2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS